| http://purl.uniprot.org/citations/8681956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8681956 | http://www.w3.org/2000/01/rdf-schema#comment | "The zeta polypeptide is part of the T cell antigen receptor (TCR). The zeta-chain contributes to efficient cell-surface expression of the TCR and accounts for part of its signal transduction capability. TCR recognition triggers a complex set of events that result in cellular activation. The protein tyrosine kinase (PTK) Lck phosphorylates the zeta-chain, which in turn associates with another PTK, ZAP70, and stimulates its phosphorylation activity. Here we report the expression of the intracellular part of the zeta-chain and its biochemical characterization. The recombinant protein does not dimerize by itself in solution. Circular-dichroic analysis reveals a random coil conformation. zeta, phosphorylated using recombinant Lck, associates with recombinant ZAP70 tandem-SH2 domains. All three T cell activation motifs in zeta bind ZAP70 tandem-SH2 domains in vitro, forming a 1:3 complex. This result extends the picture, derived from earlier studies, of a mechanism for signal amplification."xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1996.0440z.x"xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/author | "Eck M.J."xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/author | "Harrison S.C."xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/author | "Wiley D.C."xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/author | "Weissenhorn W."xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/name | "Eur J Biochem"xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/pages | "440-445"xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/title | "Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro."xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://purl.uniprot.org/core/volume | "238"xsd:string |
| http://purl.uniprot.org/citations/8681956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8681956 |
| http://purl.uniprot.org/citations/8681956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8681956 |
| http://purl.uniprot.org/uniprot/P20963#attribution-05A2A199A688F215A0C7669DA65BCC1A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8681956 |
| http://purl.uniprot.org/uniprot/P06239#attribution-05A2A199A688F215A0C7669DA65BCC1A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8681956 |
| http://purl.uniprot.org/uniprot/P06239#attribution-8D006863764232BEA5BF457C998C51FD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8681956 |