| http://purl.uniprot.org/citations/8702901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8702901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8702901 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify new dimerization partners for the aromatic hydrocarbon receptor nuclear translocator (Arnt), we used its N-terminal region (amino acids 1-470) as a target in a two-hybrid screening procedure, and we cloned the murine form of hypoxia-inducible factor 1alpha (HIF1alpha). Sequence comparisons reveal substantial identity between mouse and human HIF1alpha. Hypoxia induces a 10-fold accumulation of phosphoglycerate kinase 1 mRNA in wild type mouse hepatoma (Hepa 1c1c7) cells; the induction mechanism is Arnt dependent because induction does not occur in Arnt-defective cells. Furthermore, induction of phosphoglycerate kinase 1 mRNA requires Arnt's N-terminal region, which mediates DNA binding and heterodimerization; in contrast, induction does not require Arnt's C-terminal region, which mediates transactivation. We also show that a GAL4-HIF1alpha fusion protein transactivates a GAL4-dependent gene in the absence of Arnt, that HIF1alpha's transactivation capability is inducible by hypoxia, and that both hypoxia responsiveness and transactivation capability reside within the C-terminal 83 amino acids of HIF1alpha. Our findings generate new insights into the mechanism by which Arnt and HIF1alpha induce transcription in response to hypoxia."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.35.21262"xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.35.21262"xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/author | "Whitlock J.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/author | "Whitlock J.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/author | "Ko H.P."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/author | "Ko H.P."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/pages | "21262-21267"xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/pages | "21262-21267"xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/title | "Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/title | "Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha."xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8702901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8702901 |
| http://purl.uniprot.org/citations/8702901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8702901 |
| http://purl.uniprot.org/citations/8702901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8702901 |
| http://purl.uniprot.org/citations/8702901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8702901 |