RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/8752219http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8752219http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8752219http://www.w3.org/2000/01/rdf-schema#comment"Typified by rapid degeneration of sensory neurons, dystonia musculorum mice have a defective BPAG1 gene, known to be expressed in epidermis. We report a neuronal splice form, BPAG1n, which localizes to sensory axons. Both isoforms have a coiled-coil rod, followed by a carboxy domain that associates with intermediate filaments. However, the amino terminus of BPAG1n differs from BPAG1e in that it contains a functional actin-binding domain. In transfected cells, BPAG1n coaligns neurofilaments and microfilaments, establishing this as a cytoskeletal protein interconnecting actin and intermediate filament cytoskeletons. In BPAG1 null mice, axonal architecture is markedly perturbed, consistent with a failure to tether neurofilaments to the actin cytoskeleton and underscoring the physiological relevance of this protein."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)80138-5"xsd:string
http://purl.uniprot.org/citations/8752219http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)80138-5"xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Yang Y."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Yang Y."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Fuchs E."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Fuchs E."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Cleveland D.W."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Cleveland D.W."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Dowling J."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Dowling J."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Kouklis P."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Kouklis P."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Yu Q.C."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/author"Yu Q.C."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/pages"655-665"xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/pages"655-665"xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/title"An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments."xsd:string
http://purl.uniprot.org/citations/8752219http://purl.uniprot.org/core/title"An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments."xsd:string