| http://purl.uniprot.org/citations/8805366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8805366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8805366 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-mismatch repair removes mismatches from the newly replicated DNA strand. In humans, mutations in the mismatch repair genes hMSH2, hMLH1, hPMS1 and hPMS2 result in hereditary non-polyposis colorectal cancer (HNPCC) [1-8]. The hMSH2 (MSH for MutS homologue) protein forms a complex with a 160 kDa protein, and this heterodimer, hMutSalpha, has high affinity for a G/T mismatch [9,10]. Cell lines in which the 160 kDa subunit of hMutSalpha is mutated are specifically defective in the repair of base-base and single-nucleotide insertion/deletion mismatches [9,11]. Genetic studies in S. cerevisiae have suggested that MSH2 functions with either MSH3 or MSH6 in mismatch repair, and, in the absence of the latter two genes, MSH2 is inactive [12,13]. MSH6 encodes the yeast counterpart of the 160 kDa subunit of hMutSalpha [12,13]. As in humans, yeast MSH6 forms a complex with MSH2, and the MSH2-MSH6 heterodimer binds a G/T mismatch [14]. Here, we find that MSH2 and MSH3 form another stable heterodimer, and we purify this heterodimer to near homogeneity. We show that MSH2-MSH3 has low affinity for a G/T mismatch but binds to insertion/deletion mismatches with high specificity, unlike MSH2-MSH6."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)70686-6"xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)70686-6"xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Prakash L."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Prakash L."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Prakash S."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Prakash S."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Habraken Y."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/author | "Habraken Y."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/pages | "1185-1187"xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/pages | "1185-1187"xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/title | "Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/title | "Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3."xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/8805366 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8805366 |
| http://purl.uniprot.org/citations/8805366 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8805366 |