| http://purl.uniprot.org/citations/8805651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8805651 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T cells mediate some of the damage to the lung epithelium following respiratory syncytial virus (RSV) infection. Since CD8+ T cells recognize antigen-laden class I MHC molecules on the target cells, we examined in this study the expression of class I MHC by RSV-infected respiratory epithelial cells. Respiratory epithelial cell lines and bronchial epithelial cells from normal human tissue responded to RSV infection with an increased expression of class I MHC as determined by flow cytometry and immunoprecipitation of class I MHC from metabolically radiolabeled cells. The increase in class I MHC expression was dependent on infectious, replicating virus. UV-irradiated culture supernatants from RSV-infected A549 cells, when added to fresh A549 cell cultures, induced an increase in class I MHC expression by those cells. The class I MHC increasing activity within supernatants from A549 cells was due, in large part, to IFN-beta, and to a lesser extent to IL-1 alpha. The addition of neutralizing Abs to both cytokines completely blocked the increase in class I MHC expression by cells treated with the above-mentioned supernatants. These results demonstrate that RSV infection elicits IFN-beta production by respiratory epithelial cells, which in turn leads to an increase in their synthesis of class I MHC, which would facilitate their recognition and lysis by RSV-specific CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Ye G."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Reyes V.E."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Baron S."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Mei F."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Espejo R."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Ogra P.L."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Garofalo R."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/author | "Haeberle H."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/pages | "2506-2513"xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/title | "Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through the induction of IFN-beta and IL-1 alpha."xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://purl.uniprot.org/core/volume | "157"xsd:string |
| http://purl.uniprot.org/citations/8805651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8805651 |
| http://purl.uniprot.org/citations/8805651 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8805651 |
| http://purl.uniprot.org/uniprot/P01574#attribution-A99D1ADC73F6E9EEF25B6CD94811EDCC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8805651 |