| http://purl.uniprot.org/citations/8825648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8825648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8825648 | http://www.w3.org/2000/01/rdf-schema#comment | "bHLH-EC2 is a recently characterized member of a growing family of basic helix-loop-helix transcription factors. This family includes bHLH factors such as twist, which appear to be primarily involved in early mesodermal differentiation, and bHLH factors such as TAL-1, which have been characterized through their association with chromosomal breakpoints associated with T-cell leukemias. To provide for studies aimed at understanding the genetic regulation of bHLH-EC2, we have characterized the organization of this gene and conducted preliminary studies of the transcriptional activity of the upstream promoter region. The mouse bHLH-EC2 gene was found to consist of two exons separated by a 5-kb intron, an organization pattern similar to the mouse twist gene. The transcription initiation site was identified by RNase protection assay and primer extension analysis. Linked promoter-reporter gene transfection experiments in cultured cells indicated that while the identified upstream sequence can function to promote transcription, it does not function in a cell-specific fashion. To investigate the possible association of bHLH-EC2 with hematological malignancy, the chromosomal location of this gene in the human was mapped by fluorescence in situ hybridization and assigned to chromosome band 20p13."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1995.1282"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1995.1282"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Espinosa R."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Espinosa R."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Le Beau M.M."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Le Beau M.M."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Quertermous T."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Quertermous T."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Quertermous E.E."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Quertermous E.E."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Hidai H."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/author | "Hidai H."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/pages | "598-601"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/pages | "598-601"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/title | "Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/title | "Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2."xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/8825648 | http://purl.uniprot.org/core/volume | "30"xsd:string |