| http://purl.uniprot.org/citations/8917528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8917528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8917528 | http://www.w3.org/2000/01/rdf-schema#comment | "p300 and CBP are homologous transcription adapters targeted by the E1A oncoprotein. They participate in numerous biological processes, including cell cycle arrest, differentiation, and transcription activation. p300 and/or CBP (p300/CBP) also coactivate CREB. How they participate in these processes is not yet known. In a search for specific p300 binding proteins, we have cloned the intact cDNA for HIF-1 alpha. This transcription factor mediates hypoxic induction of genes encoding certain glycolytic enzymes, erythropoietin (Epo), and vascular endothelial growth factor. Hypoxic conditions lead to the formation of a DNA binding complex containing both HIF-1 alpha and p300/CBP. Hypoxia-induced transcription from the Epo promoter was specifically enhanced by ectopic p300 and inhibited by E1A binding to p300/CBP. Hypoxia-induced VEGF and Epo mRNA synthesis were similarly inhibited by E1A. Hence, p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including one (vascular endothelial growth factor) that plays a major role in tumor angiogenesis. Paradoxically, these data, to our knowledge for the first time, suggest that p300/ CBP are active in both transformation suppression and tumor development."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.23.12969"xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.23.12969"xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Livingston D.M."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Livingston D.M."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Arany Z."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Arany Z."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Bunn H.F."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Bunn H.F."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Eckner R."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Eckner R."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Goldberg M.A."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Goldberg M.A."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Huang L.E."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/author | "Huang L.E."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8917528 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |