| http://purl.uniprot.org/citations/8942985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8942985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8942985 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic and biochemical properties of three human MutS homologues, hMSH2, hMSH3, and hMSH6, have been examined. The full-length hMSH6 cDNA and genomic locus were isolated and characterized, and it was demonstrated that the hMSH6 gene consisted of 10 exons and mapped to chromosome 2p15-16. The hMSH3 cDNA was in some cases found to contain a 27-bp deletion resulting in a loss of nine amino acids, depending on the individual from which the cDNA was isolated. hMSH2, hMSH3, and hMSH6 all showed similar tissue-specific expression patterns. hMSH2 protein formed a complex with both hMSH3 and hMSH6 proteins, similar to protein complexes demonstrated by studies of the Saccharomyces cerevisiae MSH2, MSH3, and MSH6. hMSH2 was also found to form a homomultimer complex, but neither hMSH3 nor hMSH6 appear to interact with themselves or each other. Analysis of the mismatched nucleotide-binding specificity of the hMSH2-hMSH3 and hMSH2-hMSH6 protein complexes showed that they have overlapping but not identical binding specificity. These results help to explain the distribution of mutations in different mismatch-repair genes seen in hereditary nonpolyposis colon cancer."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.24.13629"xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.93.24.13629"xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Kane M.F."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Kane M.F."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Kolodner R.D."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Kolodner R.D."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Fishel R."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Fishel R."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Wilson T."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Wilson T."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Gradia S."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Gradia S."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Acharya S."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Acharya S."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Marsischky G.T."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Marsischky G.T."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Guerrette S."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/author | "Guerrette S."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8942985 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |