| http://purl.uniprot.org/citations/9020361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9020361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9020361 | http://www.w3.org/2000/01/rdf-schema#comment | "Several members of the tumour-necrosis/nerve-growth factor (TNF/NGF) receptor family activate the transcription factor NF-kappaB through a common adaptor protein, Traf2 (refs 1-5), whereas the interleukin 1 type-I receptor activates NF-kappaB independently of Traf2 (ref. 4). We have now cloned a new protein kinase, NIK, which binds to Traf2 and stimulates NF-kappaB activity. This kinase shares sequence similarity with several MAPKK kinases. Expression in cells of kinase-deficient NIK mutants fails to stimulate NF-kappaB and blocks its induction by TNF, by either of the two TNF receptors or by the receptor CD95 (Fas/Apo-1), and by TRADD, RIP and MORT1/FADD, which are adaptor proteins that bind to these receptors. It also blocked NF-kappaB induction by interleukin-1. Our findings indicate that NIK participates in an NF-kappaB-inducing signalling cascade common to receptors of the TNF/NGF family and to the interleukin-1 type-I receptor."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.org/dc/terms/identifier | "doi:10.1038/385540a0"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.org/dc/terms/identifier | "doi:10.1038/385540a0"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Wallach D."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Wallach D."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Boldin M.P."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Boldin M.P."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Kovalenko A.V."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Kovalenko A.V."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Malinin N.L."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/author | "Malinin N.L."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/pages | "540-544"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/pages | "540-544"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/title | "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/title | "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1."xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/volume | "385"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://purl.uniprot.org/core/volume | "385"xsd:string |
| http://purl.uniprot.org/citations/9020361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9020361 |
| http://purl.uniprot.org/citations/9020361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9020361 |