| http://purl.uniprot.org/citations/9038134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9038134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9038134 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of resting T lymphocytes is initiated by rapid but transient tyrosine phosphorylation of a number of cellular proteins. Several protein tyrosine kinases and protein tyrosine phosphatases are known to be important for this response. Here we report that normal T lymphocytes express the B isoform of low molecular weight protein tyrosine phosphatase B (LMPTP-B). The cDNA was cloned from Jurkat T cells, and an antiserum was raised against it. LMPTP immunoprecipitated from resting Jurkat T cells was found to be tyrosine phosphorylated. On stimulation of the cells through their T cell antigen receptor, the phosphotyrosine content of LMPTP-B declined rapidly. In co-transfected COS cells, Lck and Fyn caused phosphorylation of LMPTP, whereas Csk, Zap, and Jak2 did not. Most of the phosphate was located at Tyr-131, and some was also located at Tyr-132. Incubation of wild-type LMPTP with Lck and adenosine 5'-O-(thiotriphosphate) caused a 2-fold increase in the activity of LMPTP. Site-directed mutagenesis showed that Tyr-131 is important for the catalytic activity of LMPTP, and that thiophosphorylation of Tyr-131, and to a lesser degree Tyr-132, is responsible for the activation."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.9.5371"xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.9.5371"xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Williams S."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Williams S."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Mustelin T."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Mustelin T."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Couture C."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Couture C."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Tailor P."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Tailor P."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Gilman J."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/author | "Gilman J."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/pages | "5371-5374"xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/pages | "5371-5374"xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/title | "Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/title | "Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132."xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9038134 | http://purl.uniprot.org/core/volume | "272"xsd:string |