| http://purl.uniprot.org/citations/9152628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9152628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9152628 | http://www.w3.org/2000/01/rdf-schema#comment | "We carried out screening for mutations in the GH-1 gene in 29 sporadic Japanese subjects with severe Isolated Growth Hormone Deficiency (IGHD) by dideoxy fingerprinting (ddF). Three of 29 (approximately 10%) were heterozygous for each of the following GH-1 gene mutations including: 1) an G-->A transition in the third codon of the GH-1 signal peptide of exon 1 resulting in a Threonine to Alanine substitution, 2) a G-->A transition in the first base of the donor splice site of IVS 3 (+1G-->A) and 3) a G-->A transition in the 183rd codon of the GH-1 mature peptide of exon 5 resulting in an Arginine to Histidine substitution. One of three was heterozygous for both mutations of 1) and 2). The IVS 3 (+1G-->A) mutation has been previously reported in affected individuals from three unrelated families with IGHD type II (autosomal dominant form). This mutation destroys the GH IVS 3 donor splice site, causing skipping of exon 3 and loss of the codons for amino acids 32-71 of the mature GH peptide. Our findings indicate that 1) ddF screening of genomic DNAs provides a practical tool to detect GH gene mutations and 2) some sporadic cases of IGHD may be caused by GH gene alternations."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.org/dc/terms/identifier | "doi:10.1507/endocrj.44.149"xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.org/dc/terms/identifier | "doi:10.1507/endocrj.44.149"xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Ogawa M."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Ogawa M."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Kamijo T."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Kamijo T."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Phillips J.A. III"xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Phillips J.A. III"xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Prince M.A."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Prince M.A."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Miyata I."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Miyata I."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Cogan J.D."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/author | "Cogan J.D."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/name | "Endocr. J."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/name | "Endocr. J."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/pages | "149-154"xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/pages | "149-154"xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/title | "Detection of growth hormone gene defects by dideoxy fingerprinting (ddF)."xsd:string |
| http://purl.uniprot.org/citations/9152628 | http://purl.uniprot.org/core/title | "Detection of growth hormone gene defects by dideoxy fingerprinting (ddF)."xsd:string |