| http://purl.uniprot.org/citations/9154802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9154802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9154802 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel human cDNA, CHES1 (checkpoint suppressor 1), has been isolated by suppression of the mec1-1 checkpoint mutation in Saccharomyces cerevisiae. CHES1 suppresses a number of DNA damage-activated checkpoint mutations in S. cerevisiae, including mec1, rad9, rad24, dun1, and rad53. CHES1 suppression of sensitivity to DNA damage is specific for checkpoint-defective strains, in contrast to DNA repair-defective strains. Presence of CHES1 but not a control vector resulted in G2 delay after UV irradiation in checkpoint-defective strains, with kinetics, nuclear morphology, and cycloheximide resistance similar to those of a wild-type strain. CHES1 can also suppress the lethality, UV sensitivity, and G2 checkpoint defect of a mec1 null mutation. In contrast to this activity, CHES1 had no measurable effect on the replication checkpoint as assayed by hydroxyurea sensitivity of a mec1 strain. Sequence analysis demonstrates that CHES1 is a novel member of the fork head/Winged Helix family of transcription factors. Suppression of the checkpoint-defective phenotype requires a 200-amino-acid domain in the carboxy terminus of the protein which is distinct from the DNA binding site. Analysis of CHES1 activity is most consistent with activation of an alternative MEC1-independent checkpoint pathway in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.6.3037"xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.6.3037"xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Keller C."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Keller C."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Plon S.E."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Plon S.E."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Pati D."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Pati D."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Groudine M."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/author | "Groudine M."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/pages | "3037-3046"xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/pages | "3037-3046"xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/title | "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/title | "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA."xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9154802 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9154802 |
| http://purl.uniprot.org/citations/9154802 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9154802 |