| http://purl.uniprot.org/citations/9154825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9154825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9154825 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe a new minichromosome maintenance factor, Mcm10, and show that this essential protein is involved in the initiation of DNA replication in Saccharomyces cerevisiae. The mcm10 mutant has an autonomously replicating sequence-specific minichromosome maintenance defect and arrests at the nonpermissive temperature with dumbbell morphology and 2C DNA content. Mcm10 is a nuclear protein that physically interacts with several members of the MCM2-7 family of DNA replication initiation factors. Cloning and sequencing of the MCM10 gene show that it is identical to DNA43, a gene identified independently for its putative role in replicating DNA. Two-dimensional DNA gel analysis reveals that the mcm10-1 lesion causes a dramatic reduction in DNA replication initiation at chromosomal origins, including ORI1 and ORI121. Interestingly, the mcm10-1 lesion also causes replication forks to pause during elongation through these same loci. This novel phenotype suggests a unique role for the Mcm10 protein in the initiation of DNA synthesis at replication origins."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.6.3261"xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.6.3261"xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Kawasaki Y."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Kawasaki Y."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Tye B.K."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Tye B.K."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Merchant A.M."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/author | "Merchant A.M."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/pages | "3261-3271"xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/pages | "3261-3271"xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/title | "A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/title | "A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9154825 | http://purl.uniprot.org/core/volume | "17"xsd:string |