| http://purl.uniprot.org/citations/9171827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9171827 | http://www.w3.org/2000/01/rdf-schema#comment | "Structural alterations of the promoter region of the BCL-6 proto-oncogene represent the most frequent genetic alteration associated with non-Hodgkin lymphoma, a malignancy often deriving from germinal-centre B cells. The BCL-6 gene encodes a zinc-finger transcriptional repressor normally expressed in both B cells and CD4+ T cells within germinal centres, but its precise function is unknown. We show that mice deficient in BCL-6 displayed normal B-cell, T-cell and lymphoid-organ development but have a selective defect in T-cell-dependent antibody responses. This defect included a complete lack of affinity maturation and was due to the inability of follicular B cells to proliferate and form germinal centres. In addition, BCL-6-deficient mice developed an inflammatory response in multiple organs characterized by infiltrations of eosinophils and IgE-bearing B lymphocytes typical of a Th2-mediated hyperimmune response. Thus, BCL-6 functions as a transcriptional switch that controls germinal centre formation and may also modulate specific T-cell-mediated responses. Altered expression of BCL-6 in lymphoma represents a deregulation of the pathway normally leading to B cell proliferation and germinal centre formation."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0697-161"xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Stall A.M."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Dalla-Favera R."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Hawe N."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Ye B.H."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Chaganti R.S."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Cattoretti G."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Orazi A."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Rothman P."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Leung C."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "Nouri-Shirazi M."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/author | "de Waard R."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/pages | "161-170"xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/title | "The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation."xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/9171827 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9171827 |
| http://purl.uniprot.org/citations/9171827 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9171827 |
| http://purl.uniprot.org/uniprot/P41183#attribution-54B0CEFE06C4425FC02B44DEB050D63B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9171827 |