| http://purl.uniprot.org/citations/9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9176392 | http://www.w3.org/2000/01/rdf-schema#comment | "Induction of Bcl-2 and Bcl-x has been demonstrated in mitogen-stimulated lymphocytes in vitro, suggesting that these two apoptosis modulators may also play a role during proliferation. To explore this possibility in a physiological setting, mRNA expression of various Bcl-2 family members was examined during liver regeneration induced by partial hepatectomy, a well characterized in vivo model of cell cycle progression. After a 60% partial hepatectomy in C3H/HeN mice, the steady-state levels of Bcl-x mRNA exhibited a cyclical pattern, with peaks at 4 hours (early G1) and 48 to 72 hours (G1 phase of the second hepatocyte cell cycle). A1 and Bcl-2 mRNA were not detected, and the levels of two Mcl-1 mRNA species remained low without significant changes. The three pro-apoptotic members of the family, Bak, Bad, and Bax, all showed an early decline in mRNA levels when Bcl-x transcripts increased, followed by later peaks at 12, 24, and 48 to 72 hours, respectively. Experiments were subsequently conducted in C3H/HeJ mice, an endotoxin-resistant strain with slower liver regeneration marked by a protracted G1 phase. Even though immediate-early gene responses measured by c-myc induction remained intact, the timing of Bcl-x mRNA expression was delayed in C3H/HeJ mice. When C3H/HeN mice were pretreated with cycloheximide before hepatectomy, the early peak of Bcl-x mRNA at 4 hours was essentially abrogated whereas the immediate-early gene c-myc was hyperinduced, thus implicating Bcl-x as a delayed early response gene during liver regeneration. Bcl-x was localized in hepatocytes and by both immunohistochemistry and Western blot analysis, Bcl-xL protein reached highest levels at 12 hours (mid-G1), consistent with the expression of a delayed early gene. In summary, the expression profiles of Bcl-2 family members during liver regeneration suggest a cell-cycle-dependent regulation as well as a physiological role for these apoptosis-modulating genes during growth and proliferation."xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/author | "Hockenbery D.M."xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/author | "Fausto N."xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/author | "Tzung S.P."xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/pages | "1985-1995"xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/title | "Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene."xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/9176392 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9176392 |
| http://purl.uniprot.org/citations/9176392 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9176392 |
| http://purl.uniprot.org/uniprot/Q61337#attribution-1487912BE482DCF58E2A72A06FE114A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/O08734#attribution-1487912BE482DCF58E2A72A06FE114A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/Q64373#attribution-1487912BE482DCF58E2A72A06FE114A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/Q07813#attribution-1487912BE482DCF58E2A72A06FE114A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_P10417-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT35-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT81-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA4-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_A0A494BBC4-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_F7CUQ1-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS13-mappedCitation-9176392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9176392 |