| http://purl.uniprot.org/citations/9207062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9207062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9207062 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutagenic abasic (AP) sites are generated directly by DNA-damaging agents or by DNA glycosylases acting in base excision repair. AP sites are corrected via incision by AP endonucleases, removal of deoxyribose 5-phosphate, repair synthesis, and ligation. Mammalian DNA polymerase beta (Polbeta) carries out most base excision repair synthesis and also can excise deoxyribose 5-phosphate after AP endonuclease incision. Yeast two-hybrid analysis now indicates protein-protein contact between Polbeta and human AP endonuclease (Ape protein). In vitro, binding of Ape protein to uncleaved AP sites loads Polbeta into a ternary complex with Ape and the AP-DNA. After incision by Ape, only Polbeta exhibits stable DNA binding. Kinetic experiments indicated that Ape accelerates the excision of 5'-terminal deoxyribose 5-phosphate by Polbeta. Thus, the two central players of the base excision repair pathway are coordinated in sequential reactions."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.14.7166"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.14.7166"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Wong D."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Wong D."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Demple B."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Demple B."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Wilson D.M. III"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Wilson D.M. III"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Bennett R.A."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/author | "Bennett R.A."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/pages | "7166-7169"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/pages | "7166-7169"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/title | "Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/title | "Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway."xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9207062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9207062 |
| http://purl.uniprot.org/citations/9207062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9207062 |