| http://purl.uniprot.org/citations/9226368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9226368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9226368 | http://www.w3.org/2000/01/rdf-schema#comment | "Edg-1, an immediate-early gene induced during the in vitro differentiation of human endothelial cells, encodes a G-protein-coupled receptor (GPR) that signals via the G(i)/mitogen-activated protein kinase (MAP kinase) pathway (Lee, M.-J., Evans, M., and Hla, T. (1996) J. Biol. Chem. 271, 11272-11279). It is a prototypical member of the subfamily of "orphan" receptors that are expressed in the cardiovascular and nervous systems. In this report, the mouse edg-1 gene was cloned and sequenced, and its expression patterns were defined. The edg-1 transcript was expressed in a wide variety of adult tissues including the brain, lung, liver, heart, and spleen. However, during embryogenesis, the edg-1 mRNA was induced late in development (after Embryonic Day 15.5) at centers of ossification. As a first step toward understanding the molecular basis of tissue-specific and inducible expression, the mouse edg-1 gene and its promoter were characterized. The mouse edg-1 gene is composed of two exons and is 4.9 kb in length. The second exon is large and contains the entire coding region and the 3'-untranslated region. The edg-1 promoter is TATA-less and contains GC-rich elements, and transcription initiation occurs from a single start site. The 5'-flanking region of the promoter contains several enhancer elements. However, the activity of the 5'-flanking region was suppressed by the repressor activity within the first intron. These data provide the basis for the further characterization of the regulation of the orphan GPR edg-1."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1997.4759"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1997.4759"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/author | "Liu C.H."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/author | "Liu C.H."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/author | "Hla T."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/author | "Hla T."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/pages | "15-24"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/pages | "15-24"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/title | "The mouse gene for the inducible G-protein-coupled receptor edg-1."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/title | "The mouse gene for the inducible G-protein-coupled receptor edg-1."xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/9226368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9226368 |
| http://purl.uniprot.org/citations/9226368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9226368 |
| http://purl.uniprot.org/citations/9226368 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9226368 |
| http://purl.uniprot.org/citations/9226368 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9226368 |
| http://purl.uniprot.org/uniprot/O08530 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9226368 |
| http://purl.uniprot.org/embl-cds/AAC53294.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9226368 |