| http://purl.uniprot.org/citations/9275205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9275205 | http://www.w3.org/2000/01/rdf-schema#comment | "An early stage in thymocyte development, after rearrangement of the beta chain genes of the T cell receptor (TCR), involves expression of the pre-TCR complex and accompanying differentiation of CD4(-)CD8(-) double negative (DN) cells to CD4(+)CD8(+) double positive (DP) cells. The ZAP-70 and Syk tyrosine kinases each contain two N-terminal SH2 domains that bind phosphorylated motifs in antigen receptor subunits and are implicated in pre-T receptor signaling. However, mice deficient in either ZAP-70 or Syk have no defect in the formation of DP thymocytes. Here we show that, in mice lacking both Syk and ZAP-70, DN thymocytes undergo beta chain gene rearrangement but fail to initiate clonal expansion and are incapable of differentiating into DP cells after expression of the pre-TCR. These data suggest that the ZAP-70 and Syk tyrosine kinases have crucial but overlapping functions in signaling from the pre-TCR and hence in early thymocyte development."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.18.9797"xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Anderson S.J."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Loh D.Y."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Negishi I."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Chan A.C."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Cheng A.M."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/author | "Bolen J."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/pages | "9797-9801"xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/title | "The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9275205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9275205 |
| http://purl.uniprot.org/citations/9275205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9275205 |
| http://purl.uniprot.org/uniprot/P48025#attribution-A6CB0A8A28A4F03A21E019B894F63767 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9275205 |
| http://purl.uniprot.org/uniprot/P43404#attribution-A6CB0A8A28A4F03A21E019B894F63767 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9275205 |
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| http://purl.uniprot.org/uniprot/#_P48025-mappedCitation-9275205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9275205 |
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