| http://purl.uniprot.org/citations/9284755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9284755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9284755 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelin-1 (ET-1) is a potent vasoactive peptide in stem villi vessels, which are considered to be the major sites of placental vascular resistance. To investigate the influence of pregnancy-specific hormonal environment on ET and ET receptor (ET-R) expression, we first developed and characterized a culture of vascular smooth muscle cells from stem villi vessels. Secondly, we investigated whether the muscular layer of stem villi vessels could be a site of the ET expression described in the placenta, and we examined this expression in placental vascular smooth muscle cells (PVSMCs). Prepro-ET-1 and prepro-ET-3 messenger ribonucleic acid (mRNA) were identified in stem villi vessels, whereas only prepro-ET-1 mRNA was observed in PVSMCs. Third, with the goal of using PVSMCs as ET target cells, we characterized the ET-R expressed by these cells in comparison with the muscular layer of stem villi vessels. Whereas both ETA-R and ETB-R are present in stem villi vessels, we found that PVSMCs express exclusively ETA-R. In addition to the previously reported ETA-R spliced transcripts, we described a new ETA-R transcript, ETA-R delta 3, generated by exclusion of exon 3 in stem villi vessels and PVSMCs. Alternative splicing mechanisms of ETA-R mRNA could constitute a control of the abundance of active ETA-R in terms of contractility. PVSMCs will be a useful model to study the environmental stimuli involved in the regulation of ET and ET-R expression in the muscular layer of feto-placental vasculature."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.org/dc/terms/identifier | "doi:10.1210/jcem.82.9.4209"xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.org/dc/terms/identifier | "doi:10.1210/jcem.82.9.4209"xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Ferre F."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Ferre F."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Robert B."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Robert B."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Bourgeois C."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Bourgeois C."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Duc-Goiran P."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Duc-Goiran P."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Mignot T.-M."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Mignot T.-M."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Mondon F."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Mondon F."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Rebourcet R."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/author | "Rebourcet R."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/name | "J. Clin. Endocrinol. Metab."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/name | "J. Clin. Endocrinol. Metab."xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/pages | "3116-3123"xsd:string |
| http://purl.uniprot.org/citations/9284755 | http://purl.uniprot.org/core/pages | "3116-3123"xsd:string |