| http://purl.uniprot.org/citations/9312026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9312026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9312026 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Myc protein activates transcription as part of a heteromeric complex with Max. However, Myc-transformed cells are characterized by loss of expression of several genes, suggesting that Myc may also repress gene expression. Two-hybrid cloning identifies a novel POZ domain Zn finger protein (Miz-1; Myc-interacting Zn finger protein-1) that specifically interacts with Myc, but not with Max or USF. Miz-1 binds to start sites of the adenovirus major late and cyclin D1 promoters and activates transcription from both promoters. Miz-1 has a potent growth arrest function. Binding of Myc to Miz-1 requires the helix-loop-helix domain of Myc and a short amphipathic helix located in the carboxy-terminus of Miz-1. Expression of Myc inhibits transactivation, overcomes Miz-1-induced growth arrest and renders Miz-1 insoluble in vivo. These processes depend on Myc and Miz-1 association and on the integrity of the POZ domain of Miz-1, suggesting that Myc binding activates a latent inhibitory function of this domain. Fusion of a nuclear localization signal induces efficient nuclear transport of Miz-1 and impairs the ability of Myc to overcome transcriptional activation and growth arrest by Miz-1. Our data suggest a model for how gene repression by Myc may occur in vivo."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.18.5672"xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.18.5672"xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Schneider A."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Schneider A."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Haenel F."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Haenel F."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Eilers M."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Eilers M."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Carmichael G."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Carmichael G."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Peukert K."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Peukert K."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Staller P."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/author | "Staller P."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/pages | "5672-5686"xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/pages | "5672-5686"xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/title | "An alternative pathway for gene regulation by Myc."xsd:string |
| http://purl.uniprot.org/citations/9312026 | http://purl.uniprot.org/core/title | "An alternative pathway for gene regulation by Myc."xsd:string |