| http://purl.uniprot.org/citations/9380701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9380701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9380701 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified and characterized CLARP, a caspase-like apoptosis-regulatory protein. Sequence analysis revealed that human CLARP contains two amino-terminal death effector domains fused to a carboxyl-terminal caspase-like domain. The structure and amino acid sequence of CLARP resemble those of caspase-8, caspase-10, and DCP2, a Drosophila melanogaster protein identified in this study. Unlike caspase-8, caspase-10, and DCP2, however, two important residues predicted to be involved in catalysis were lost in the caspase-like domain of CLARP. Analysis with fluorogenic substrates for caspase activity confirmed that CLARP is catalytically inactive. CLARP was found to interact with caspase-8 but not with FADD/MORT-1, an upstream death effector domain-containing protein of the Fas and tumor necrosis factor receptor 1 signaling pathway. Expression of CLARP induced apoptosis, which was blocked by the viral caspase inhibitor p35, dominant negative mutant caspase-8, and the synthetic caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethylketone (zVAD-fmk). Moreover, CLARP augmented the killing ability of caspase-8 and FADD/MORT-1 in mammalian cells. The human clarp gene maps to 2q33. Thus, CLARP represents a regulator of the upstream caspase-8, which may play a role in apoptosis during tissue development and homeostasis."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.20.10717"xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.20.10717"xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Koseki T."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Koseki T."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/pages | "10717-10722"xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/pages | "10717-10722"xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/title | "CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/title | "CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis."xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9380701 | http://purl.uniprot.org/core/volume | "94"xsd:string |