| http://purl.uniprot.org/citations/9460655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9460655 | http://www.w3.org/2000/01/rdf-schema#comment | "Our previous studies indicated that PI3-kinase is involved in prolactin (PRL) signalling. We have now examined the involvement of the src tyrosine kinase, fyn, in PRL-induced the activation of PI3-kinase in the rat lymphoma cell line, Nb2. Cells were stimulated with increasing doses of PRL, lysed and immunoprecipitated with anti-fyn specific antibody. Then PI3-kinase activity was measured as the increase in the phosphorylation of phosphatidylinositol to phosphatidylinositol 3-phosphate separated by TLC. Our data indicated that, in PRL treated cells, co-precipitation of PI3-kinase with anti-fyn antiserum led to time and dose-dependent activation of PI3-kinase in vitro and that this activation was blocked by the addition of LY294002. However, LY294002 appeared to have no effect on fyn autophosphorylation. Furthermore, the physical association of PI3-kinase with fyn was confirmed by Western blot analysis employing the same specific antisera. These data provide evidence that PRL-induced activation of PI3-kinase may be mediated by the tyrosine phosphorylation of fyn in Nb2 cells."xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.org/dc/terms/identifier | "doi:10.1677/jme.0.0190347"xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/author | "Brown B.L."xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/author | "Dobson P.R."xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/author | "al-Sakkaf K.A."xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/name | "J Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/pages | "347-350"xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/title | "Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells."xsd:string |
| http://purl.uniprot.org/citations/9460655 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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