| http://purl.uniprot.org/citations/9469451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9469451 | http://www.w3.org/2000/01/rdf-schema#comment | "The chemokine RANTES is a potent agonist of T cell activation. In an investigation of signal-transduction events activated by this chemokine, we have shown that RANTES stimulates dose-dependent phospholipase D (PLD) activity in Jurkat cells. Equilibrium-binding analyses using 125I-labeled RANTES indicated the presence of a receptor for RANTES on these cells, which has a Kd of 0.1 nM, is expressed at approximately 600 sites per cell, and a binding specificity that was not comparable with that of any of the known chemokine receptors, since 125I-labeled RANTES was displaced by macrophage-inflammatory protein-1 beta (but not macrophage-inflammatory protein-1 alpha), monocyte-chemotactic protein-1 (MCP-1), MCP-3, MCP-4, and eotaxin. RANTES-induced PLD activation was augmented by GTP gamma S, but not GDP beta S, and inhibited by the protein kinase C inhibitor bisindolylmaleimide, as well as the fungal metabolite brefeldin A, and C3 exoenzyme (Clostridium botulinum), implicating the activation of RhoA. RANTES also induced GTP-GDP exchange of immunoprecipitated RhoA. RANTES-stimulated PLD activity was dependent on an ADP-ribosylation factor(s), as assessed by inhibition studies using a synthetic inhibitory peptide of the N-terminal 16 amino acids of ADP-ribosylation factor 1. These studies indicate the potential existence of a novel receptor-mediated mechanism for activation of T cells by the chemokine RANTES."xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/author | "Dairaghi D.J."xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/author | "Schall T.J."xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/author | "Bacon K.B."xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/pages | "1894-1900"xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/title | "RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA."xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/9469451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9469451 |
| http://purl.uniprot.org/citations/9469451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9469451 |
| http://purl.uniprot.org/uniprot/P13501#attribution-1FAA150E699750DF5109397C18197A16 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9469451 |