| http://purl.uniprot.org/citations/9514871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9514871 | http://www.w3.org/2000/01/rdf-schema#comment | "At present, the mechanism of replication of the HCV genome remains unclear. Recently, NS5B and NS3 of HCV have been shown to exhibit RNA-dependent RNA polymerase and helicase activities, respectively, both of which are indispensable for virus RNA replication. In this study, we examined the complex formation of NS5B with NS3 and NS4A, a cofactor for NS3. We show here that NS5B forms a complex with NS3 through an amino-terminal portion of NS3. The NS3-NS5B complex formation took place both in the presence and absence of NS4A. We also demonstrate that NS5B form a complex with NS4A in the absence of NS3. These results suggest that NS3, NS4A and NS5B interact with each other to form a complex that functions as part of the replication machinery of HCV."xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.8202"xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/author | "Hotta H."xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/author | "Ishido S."xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/pages | "35-40"xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/title | "Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus."xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://purl.uniprot.org/core/volume | "244"xsd:string |
| http://purl.uniprot.org/citations/9514871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9514871 |
| http://purl.uniprot.org/citations/9514871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9514871 |