| http://purl.uniprot.org/citations/9535930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9535930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9535930 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the cloning of a novel human activator of c-Jun N-terminal kinase (JNK), mitogen-activated protein kinase kinase 7 (MKK7). The mRNA for MKK7 is widely expressed in humans and mice and encodes a 47-kDa protein (419 amino acids), as determined by immunoblotting endogenous MKK7 with an antibody raised against its N terminus. The kinase domain of MKK7 is closely related to a Drosophila JNK kinase dHep (69% identity) and to a newly identified ortholog from Caenorhabditis elegans (54% identity), and was more distantly related to MKK4, MKK3, and MKK6. MKK7 phosphorylated and activated JNK1 but failed to activate p38 MAPK in co-expression studies. In hematopoietic cells, endogenous MKK7 was activated by treatment with the growth factor interleukin-3 (but not interleukin-4), or by ligation of CD40, the B-cell antigen receptor, or the receptor for the Fc fragment of immunoglobulin. MKK7 was also activated when cells were exposed to heat, UV irradiation, anisomycin, hyperosmolarity or the pro-inflammatory cytokine tumor necrosis factor-alpha. Co-expression of constitutively active mutants of RAS, RAC, or CDC42 in HeLa epithelial cells or of RAC or CDC42 in Ba/F3 factor-dependent hematopoietic cells also activated MKK7, suggesting that MKK7 will be involved in many physiological pathways."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.15.9344"xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.15.9344"xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Schrader J.W."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Schrader J.W."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Salmon R.A."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Salmon R.A."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Foltz I.N."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Foltz I.N."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Gerl R.E."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Gerl R.E."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Luckach M."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Luckach M."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Wieler J.S."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/author | "Wieler J.S."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/pages | "9344-9351"xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/pages | "9344-9351"xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/title | "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli."xsd:string |
| http://purl.uniprot.org/citations/9535930 | http://purl.uniprot.org/core/title | "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli."xsd:string |