| http://purl.uniprot.org/citations/9548483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9548483 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent molecular evidence points to transient and/or stage-specific expression of delta- and kappa-opioid receptors by thymic and peripheral T lymphocytes. Since medical treatments or stress commonly increase opioid levels, it is important to understand the mechanisms by which opioids affect T lymphocyte functions. We therefore created and studied a T cell line expressing the cloned delta-opioid receptor (DOR1). DOR1 ligation by a specific DOR1 agonist, deltorphin, augmented IL-2 secretion by synergizing with signals from TCR-CD3 and CD28. Reporter gene constructs were used to map this effect of deltorphin to the AP-1- and NF-AT/AP-1-binding sites of the IL-2 promoter. Although DOR1 signaling increased [Ca2+]i, deltorphin enhanced transcriptional activity of the NF-AT/AP-1-binding site via a mechanism independent of calcineurin and distinct from the effects of elevated [Ca2+]i. Deltorphin also increased accumulation of AP-1 transcription factor complexes, suggesting that DOR1 augments IL-2 secretion by increasing the AP-1 component of the NF-AT/AP-1 transcription factor. These results advance the molecular understanding of opioid effects on lymphocytes, and in addition, demonstrate regulation of IL-2 synthesis and secretion by the novel mechanism of receptor-mediated AP-1 induction."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/author | "Bell M.P."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/author | "Huntoon C.J."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/author | "McKean D.J."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/author | "Hedin K.E."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/author | "Kalli K.R."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/author | "Sharp B.M."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/pages | "5431-5440"xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/title | "Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element."xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/9548483 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9548483 |
| http://purl.uniprot.org/citations/9548483 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9548483 |
| http://purl.uniprot.org/uniprot/P41143#attribution-8D4576CD748C097BE4099D1B5BB9A93B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9548483 |
| http://purl.uniprot.org/uniprot/P41143#attribution-ED5992B7E803DFC0A4766DA96483FF4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9548483 |