| http://purl.uniprot.org/citations/9566955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9566955 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factors (FGFs) are believed to play a key role in tissue differentiation and maturation. Thus, the expression of the four members of the high-affinity tyrosine kinase FGF receptor family (FGFRs) and of the low-affinity heparan sulphate proteoglycan binding sites, syndecan-1 and perlecan, was studied in the human skeletal muscle during development. Northern blot analysis demonstrated a developmentally regulated expression of the mRNAs for FGFR-1, FGFR-3, FGFR-4, whereas only traces of FGFR-2 mRNA were found. Each receptor type had a different developmental pattern, suggesting an independent regulation. Signal for FGFR-3 was retained only in the adult muscle. Among the low-affinity FGF binding sites, perlecan was absent, whereas RNA transcript for syndecan-1 peaked at week 13 of gestation, after which a significant decrease was observed. Immunohistochemistry for FGFRs revealed that their localization changed with muscle maturation. At early embryonic stages, FGFR-3 and FGFR-4 had a scattered distribution in the tissue, and FGFR-1 was found on myotube and myofiber plasma membranes. At later stages, FGFR-1 positivity decreased and was found in a few areas of the muscle, FGFR-3 was concentrated in the nuclei of some, but not all, muscle fibers, and FGFR-4 maintained an association with plasma membrane. In adult tissue, weak positivity for FGFR-3 and FGFR-4 was observed in the connective tissue only. When immunocytochemistry was performed on human fetal myoblasts in culture, confocal microscope analysis revealed a nonhomogeneous cell membrane distribution of FGFRs. Taken together, the data strongly suggest that developmentally regulated expression and cell distribution of FGFRs play a role during muscle maturation."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-0177(199804)211:4<362::aid-aja7>3.0.co;2-f"xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/author | "Ennas M.G."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/author | "Presta M."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/author | "Balaci L."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/author | "Dell'era P."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/author | "Gremo F."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/author | "Sogos V."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/pages | "362-373"xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/title | "Developmentally regulated expression and localization of fibroblast growth factor receptors in the human muscle."xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://purl.uniprot.org/core/volume | "211"xsd:string |
| http://purl.uniprot.org/citations/9566955 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9566955 |
| http://purl.uniprot.org/citations/9566955 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9566955 |
| http://purl.uniprot.org/uniprot/P18827#attribution-1AA195E9082CE6137E0CABE8AEC77709 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9566955 |