| http://purl.uniprot.org/citations/9590694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9590694 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) is a cytokine that was initially recognized as a regulator of immune and inflammatory responses, but it also regulates the growth of many tumour cells, including prostrate carcinoma. Overexpression of the growth-factor receptors ErbB2/neu and ErbB3 has been implicated in the neoplastic transformation of prostate carcinoma. Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. We also show that ErbB2 forms a complex with the gp130 subunit of the IL-6 receptor in an IL-6-dependent manner. This association is important because the inhibition of ErbB2 activity results in abrogation of IL-6-induced MAPK activation. Thus ErbB2 is a critical component of IL-6 signalling through the MAP kinase pathway. These data show how a cytokine receptor can diversify its signalling pathways by engaging with a growth-factor receptor kinase."xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.org/dc/terms/identifier | "doi:10.1038/30012"xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/author | "Kung H.J."xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/author | "Ravi L."xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/pages | "83-85"xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/title | "Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://purl.uniprot.org/core/volume | "393"xsd:string |
| http://purl.uniprot.org/citations/9590694 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9590694 |
| http://purl.uniprot.org/citations/9590694 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9590694 |
| http://purl.uniprot.org/uniprot/P04626#attribution-24FFB439BBC34F40C0F6203715BFE70A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9590694 |