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http://purl.uniprot.org/citations/9628587http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9628587http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9628587http://www.w3.org/2000/01/rdf-schema#comment"Contact is a vital mechanism used by cells to interact with their environment. Contact with living and nonliving elements adjacent to a cell is the basis for many common biological events ranging from growth regulation to metastasis to embryonic pattern formation. We describe the cloning and characterization of a novel density-regulated protein (drp) whose expression is increased in cultured cells at high density compared with cells at low density. A drp cDNA was isolated from the human teratocarcinoma cell line PA-1. Northern analysis with a drp probe revealed transcripts of 2.8 and 3.2 kb. The drp RNA was expressed in a variety of tissues, with the highest amounts in skeletal and cardiac muscle. Using antipeptide antisera, increasing amounts of a 70-kDa protein were detected using several experimental approaches in several cells lines as cell density is increased. Conditioned medium from high-density cells was unable to induce expression of drp in cells growing at low density. Similarly, growth arrest by serum starvation or transforming growth factor-beta (TGF-beta) treatment failed to elicit drp expression. We conclude that drp is a novel protein whose expression is increased at high cell density but not growth arrest."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.org/dc/terms/identifier"doi:10.1089/dna.1998.17.437"xsd:string
http://purl.uniprot.org/citations/9628587http://purl.org/dc/terms/identifier"doi:10.1089/dna.1998.17.437"xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/author"Tainsky M.A."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/author"Tainsky M.A."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/author"Chiao P.J."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/author"Chiao P.J."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/author"Deyo J.E."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/author"Deyo J.E."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/name"DNA Cell Biol."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/name"DNA Cell Biol."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/pages"437-447"xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/pages"437-447"xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/title"Drp, a novel protein expressed at high cell density but not during growth arrest."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/title"Drp, a novel protein expressed at high cell density but not during growth arrest."xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/9628587http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/9628587http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9628587
http://purl.uniprot.org/citations/9628587http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9628587
http://purl.uniprot.org/citations/9628587http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9628587
http://purl.uniprot.org/citations/9628587http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9628587