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http://purl.uniprot.org/citations/9637679http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9637679http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9637679http://www.w3.org/2000/01/rdf-schema#comment"Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentia that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.org/dc/terms/identifier"doi:10.1101/gad.12.12.1775"xsd:string
http://purl.uniprot.org/citations/9637679http://purl.org/dc/terms/identifier"doi:10.1101/gad.12.12.1775"xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Lazar M.A."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Lazar M.A."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Carthew R.W."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Carthew R.W."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Guenther M.G."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/author"Guenther M.G."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/name"Genes Dev."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/name"Genes Dev."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/pages"1775-1780"xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/pages"1775-1780"xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/title"Proteasomal regulation of nuclear receptor corepressor-mediated repression."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/title"Proteasomal regulation of nuclear receptor corepressor-mediated repression."xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/volume"12"xsd:string
http://purl.uniprot.org/citations/9637679http://purl.uniprot.org/core/volume"12"xsd:string
http://purl.uniprot.org/citations/9637679http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9637679
http://purl.uniprot.org/citations/9637679http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9637679