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http://purl.uniprot.org/citations/9694656http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9694656http://www.w3.org/2000/01/rdf-schema#comment"The small guanosine triphosphatases (GTPases) Cdc42 and Rac1 regulate E-cadherin-mediated cell-cell adhesion. IQGAP1, a target of Cdc42 and Rac1, was localized with E-cadherin and beta-catenin at sites of cell-cell contact in mouse L fibroblasts expressing E-cadherin (EL cells), and interacted with E-cadherin and beta-catenin both in vivo and in vitro. IQGAP1 induced the dissociation of alpha-catenin from a cadherin-catenin complex in vitro and in vivo. Overexpression of IQGAP1 in EL cells, but not in L cells expressing an E-cadherin-alpha-catenin chimeric protein, resulted in a decrease in E-cadherin-mediated cell-cell adhesive activity. Thus, IQGAP1, acting downstream of Cdc42 and Rac1, appears to regulate cell-cell adhesion through the cadherin-catenin pathway."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.org/dc/terms/identifier"doi:10.1126/science.281.5378.832"xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Matsuura Y."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Nomura N."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Nakamura T."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Nakagawa M."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Kaibuchi K."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Nagase T."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Kuroda S."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Fujii K."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Yonehara S."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Fukata M."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Tani H."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Shoji I."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Izawa I."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/author"Ookubo T."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/pages"832-835"xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/title"Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion."xsd:string
http://purl.uniprot.org/citations/9694656http://purl.uniprot.org/core/volume"281"xsd:string
http://purl.uniprot.org/citations/9694656http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9694656
http://purl.uniprot.org/citations/9694656http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9694656
http://purl.uniprot.org/uniprot/#_O00255-mappedCitation-9694656http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9694656