| http://purl.uniprot.org/citations/9707618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9707618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9707618 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel member of the human frizzled (Fz) gene family was cloned and found to be specifically expressed in 3 of 13 well differentiated (23%), 13 of 20 moderately differentiated (62%), and 12 of 14 poorly differentiated (86%) squamous cell esophageal carcinomas compared with the adjacent uninvolved normal mucosa. The FzE3 cDNA encodes a protein of 574 amino acids and shares high sequence homology with the human FzD2 gene particularly in the putative ligand binding region of the cysteine-rich extracellular domain. Functional analysis revealed that transfection and expression of the FzE3 cDNA in esophageal carcinoma cells stimulates complex formation between adenomatous polyposis coli (APC) and beta-catenin followed by nuclear translocation of beta-catenin. Furthermore, cotransfection of a mutant construct encoding a FzE3 protein with a C-terminal truncation completely inhibited the interaction of APC with beta-catenin in cells. Finally, coexpression of FzE3 with Lef-1 transcription factor enhanced beta-catenin translocation to the nucleus. These observations suggest that FzE3 gene expression may down-regulate APC function and enhance beta-catenin mediated signals in poorly differentiated human esophageal carcinomas."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.17.10164"xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.17.10164"xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Wands J.R."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Wands J.R."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Sugimachi K."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Sugimachi K."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Akiyoshi T."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/author | "Akiyoshi T."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/pages | "10164-10169"xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/pages | "10164-10169"xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/title | "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/title | "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9707618 | http://purl.uniprot.org/core/volume | "95"xsd:string |