| http://purl.uniprot.org/citations/9739041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9739041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9739041 | http://www.w3.org/2000/01/rdf-schema#comment | "Winged helix transcription factors play important roles in cellular differentiation and cell-specific gene expression. To define the role of the winged helix factor hepatocyte nuclear factor/forkhead homologue (HFH)-4, a targeted mutation was created in the mouse hfh-4 gene. No expression of HFH-4 was detected in hfh-4(-)/-mice by RNA blot analysis, in situ hybridization, or RT-PCR. hfh-4(-)/-mice were noted to have abnormalities of organ situs consistent with random determination of left-right asymmetry. In addition, a complete absence of cilia was noted in hfh-4(-)/-mice. The hfh-4 gene is thus essential for nonrandom determination of left-right asymmetry and development of ciliated cells. Homozygous mutant mice also exhibited prenatal and postnatal growth failure, perinatal lethality and, in some cases, hydrocephalus. RT-PCR revealed an absence of left-right dynein (lrd) expression in the embryonic lungs of hfh-4(-)/-mice, suggesting that HFH-4 may act by regulating expression of members of the dynein family of genes. The abnormalities in ciliary development and organ situs in hfh-4(-)/-mice are similar to those observed in human congenital syndromes such as Kartagener syndrome. Targeted mutation of hfh-4 thus provides a model for elucidating the mechanisms regulating ciliary development and determination of left-right asymmetry."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci4786"xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci4786"xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Hackett B.P."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Hackett B.P."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Hebert J.L."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Hebert J.L."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Knowles H.J."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/author | "Knowles H.J."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/name | "J. Clin. Invest."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/name | "J. Clin. Invest."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/pages | "1077-1082"xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/pages | "1077-1082"xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/title | "Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/title | "Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry."xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/9739041 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9739041 |
| http://purl.uniprot.org/citations/9739041 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9739041 |