| http://purl.uniprot.org/citations/9744861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9744861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9744861 | http://www.w3.org/2000/01/rdf-schema#comment | "During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and hBrm, which are components of human SWI/SNF (hSWI/SNF) complexes, were recently shown to be phosphorylated during mitosis. This suggested that phosphorylation might be used as a switch to modulate SWI/SNF activity. Using an epitope-tag strategy, we have purified hSWI/SNF complexes at different stages of the cell cycle, and found that hSWI/SNF was inactive in cells blocked in G2-M. Mitotic hSWI/SNF contained Brg1 but not hBrm, and was phosphorylated on at least two subunits, hSWI3 and Brg1. In vitro, active hSWI/SNF from asynchronous cells can be phosphorylated and inactivated by ERK1, and reactivated by dephosphorylation. hSWI/SNF isolated as cells traversed mitosis regained activity when its subunits were dephosphorylated either in vitro or in vivo. We propose that this transitional inactivation and reactivation of hSWI/SNF is required for formation of a repressed chromatin structure during mitosis and reformation of an active chromatin structure as cells leave mitosis."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.12.18.2842"xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.12.18.2842"xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Sif S."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Sif S."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Kingston R.E."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Kingston R.E."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Stukenberg P.T."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/author | "Stukenberg P.T."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/pages | "2842-2851"xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/pages | "2842-2851"xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/title | "Mitotic inactivation of a human SWI/SNF chromatin remodeling complex."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/title | "Mitotic inactivation of a human SWI/SNF chromatin remodeling complex."xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/9744861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9744861 |
| http://purl.uniprot.org/citations/9744861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9744861 |