| http://purl.uniprot.org/citations/9751058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9751058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9751058 | http://www.w3.org/2000/01/rdf-schema#comment | "Amino-acid transport across cellular plasma membranes depends on several parallel-functioning (co-)transporters and exchangers. The widespread transport system L accounts for a sodium-independent exchange of large, neutral amino acids, whereas the system y(+)L exchanges positively charged amino acids and/or neutral amino acids together with sodium. The molecular nature of these transporters remains unknown, although expression of the human cell-surface glycoprotein 4F2 heavy chain (h4F2hc; CD98 in the mouse) is known to induce low levels of L-and/or y(+)L-type transport. This glycoprotein is found in activated lymphocytes, together with an uncharacterized, disulphide-linked lipophilic light chain with an apparent relative molecular mass of 40,000 (M(r) 40K). Here we identify the permease-related protein E16 as the first light chain of h4F2hc and show that the resulting heterodimeric complex mediates L-type amino-acid transport. The homologous protein from Schistosoma mansoni, SPRM1, also associates covalently with coexpressed h4F2hc glycoprotein, although it induces amino-acid transport of different substrate specificity. The coexpression of h4F2hc is required for surface expression of these permease-related light chains, which belong to a new family of amino-acid transporters that form heterodimers with cell-surface glycoproteins."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.org/dc/terms/identifier | "doi:10.1038/26246"xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.org/dc/terms/identifier | "doi:10.1038/26246"xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Loffing J."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Loffing J."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Mastroberardino L."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Mastroberardino L."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Pfeiffer R."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Pfeiffer R."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Shoemaker C.B."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Shoemaker C.B."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Skelly P.J."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Skelly P.J."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Spindler B."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Spindler B."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Verrey F."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/author | "Verrey F."xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/pages | "288-291"xsd:string |
| http://purl.uniprot.org/citations/9751058 | http://purl.uniprot.org/core/pages | "288-291"xsd:string |