| http://purl.uniprot.org/citations/9789057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9789057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9789057 | http://www.w3.org/2000/01/rdf-schema#comment | "The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that Tat shows conserved amino acids corresponding to critical sequences of the chemokines, a family of molecules known for their potent ability to attract monocytes. Synthetic Tat and a peptide (CysL24-51) encompassing the "chemokine-like" region of Tat induced a rapid and transient Ca2+ influx in monocytes and macrophages, analogous to beta-chemokines. Both monocyte migration and Ca2+ mobilization were pertussis toxin sensitive and cholera toxin insensitive. Cross-desensitization studies indicated that Tat shares receptors with MCP-1, MCP-3, and eotaxin. Tat was able to displace binding of beta-chemokines from the beta-chemokine receptors CCR2 and CCR3, but not CCR1, CCR4, and CCR5. Direct receptor binding experiments with the CysL24-51 peptide confirmed binding to cells transfected with CCR2 and CCR3. HIV-1 Tat appears to mimic beta-chemokine features, which may serve to locally recruit chemokine receptor-expressing monocytes/macrophages toward HIV producing cells and facilitate activation and infection."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.22.13153"xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.22.13153"xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Wells T.N.C."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Wells T.N.C."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Rabin R.L."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Rabin R.L."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Albini A."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Albini A."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Alouani S."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Alouani S."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Aluigi M.G."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Aluigi M.G."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Benelli R."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Benelli R."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Farber J.M."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Farber J.M."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Ferrini S."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Ferrini S."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Giunciuglio D."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Giunciuglio D."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Mariani G."xsd:string |
| http://purl.uniprot.org/citations/9789057 | http://purl.uniprot.org/core/author | "Mariani G."xsd:string |