| http://purl.uniprot.org/citations/9790970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9790970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9790970 | http://www.w3.org/2000/01/rdf-schema#comment | "NEDD8 is a novel ubiquitin-like protein that has been shown to conjugate to nuclear proteins in a manner analogous to ubiquitination and sentrinization. To identify proteins that are involved in the NEDD8-conjugation and de-conjugation pathway, the yeast two-hybrid system was used to screen a human heart cDNA library using NEDD8 as a bait. Seven strongly positive clones were found to contain a cDNA insert encoding the ubiquitin C-terminal hydrolase, UCH-L3. In vitro GST pull-down assay demonstrated that UCH-L3 bound to both NEDD8 and ubiquitin. In contrast, UCH-L3 did not bind to sentrin-1, sentrin-2, or sentrin-3. Recombinant UCH-L3, but not UCH-L1, was able to cleave the C-terminus of NEDD8. Thus, UCH-L3 can function as a C-terminal hydrolase for both NEDD8 and ubiquitin. UCH-L3 may play a physiologically significant role in the cleavage of the C-terminus of NEDD8, which is required for NEDD8 to conjugate to target proteins."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.9532"xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.9532"xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Wada H."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Wada H."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Kito K."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Kito K."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Yeh E.T.H."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Yeh E.T.H."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Caskey L.S."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/author | "Caskey L.S."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/pages | "688-692"xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/pages | "688-692"xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/title | "Cleavage of the C-terminus of NEDD8 by UCH-L3."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/title | "Cleavage of the C-terminus of NEDD8 by UCH-L3."xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/volume | "251"xsd:string |
| http://purl.uniprot.org/citations/9790970 | http://purl.uniprot.org/core/volume | "251"xsd:string |