| http://purl.uniprot.org/citations/9811350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9811350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9811350 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibulin-1, an extracellular matrix protein, is secreted by human ovarian metastatic cancer cell lines under estrogen stimulation. Fibulin-1 expression was quantified by immunohistochemistry and computer-aided image analysis in 44 human ovarian epithelial tumors and 14 normal ovaries. The fibulin-1 staining intensity in proximal stroma, close to the surface of epithelial cells and tumor cells, progressively increased from normal ovaries to serous carcinomas. In all lesions, excluding cystadenomas, fibulin-1 accumulation was higher in proximal stroma than in distant stroma. In situ hybridization demonstrated strong fibulin-1 gene expression in epithelial cells of serous ovarian carcinomas and some cysts. The weak expression of fibulin-1 RNA in some stromal cells of these tumors could not explain the strong fibulin-1 protein accumulation in tumor stroma, which was therefore mostly produced by tumor epithelial cells. In carcinomas, fibulin-1 staining was not correlated with the percentage of estrogen receptor-alpha (ERalpha)-stained nuclei but was inversely correlated with the progesterone receptor. However, in cystadenomas and borderline tumors, both fibulin-1 and ERalpha protein levels increased, in comparison with normal ovaries, suggesting an effect of estrogens in the early steps of tumorigenesis. This fibulin-1 overexpression, demonstrated in vivo in ovarian carcinomas, might be a useful indicator for predicting cancer risk and/or aggressiveness."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)65746-x"xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)65746-x"xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Roger P."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Roger P."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Baldet P."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Baldet P."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Lucas A."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Lucas A."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Rochefort H."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Rochefort H."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Pujol P."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/author | "Pujol P."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/pages | "1579-1588"xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/pages | "1579-1588"xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/title | "Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/title | "Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors."xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/9811350 | http://purl.uniprot.org/core/volume | "153"xsd:string |