| http://purl.uniprot.org/citations/9822622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9822622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9822622 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Arrestins mediate agonist-dependent desensitization of G protein-coupled receptors and target the receptors to clathrin-coated pits for internalization. Here we report an expanded role of beta-arrestins in promoting clathrin-mediated endocytosis of a tyrosine kinase growth factor receptor, i.e. the insulin-like growth factor I (IGF-1) receptor. beta-Arrestins bind to the ligand-occupied IGF-1 receptors, promote their endocytosis, and enhance IGF-1-dependent mitogen-activated protein kinase phosphorylation and DNA synthesis. Our results suggest a role for beta-arrestins in regulating mitogenic signaling and clathrin-mediated endocytosis of receptors not classically coupled to G proteins."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.48.31640"xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.48.31640"xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/author | "Daaka Y."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/author | "Daaka Y."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/author | "Lin F.-T."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/author | "Lin F.-T."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/pages | "31640-31643"xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/pages | "31640-31643"xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/title | "beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/title | "beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor."xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9822622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9822622 |
| http://purl.uniprot.org/citations/9822622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9822622 |
| http://purl.uniprot.org/citations/9822622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9822622 |
| http://purl.uniprot.org/citations/9822622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9822622 |