| http://purl.uniprot.org/citations/9857019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9857019 | http://www.w3.org/2000/01/rdf-schema#comment | "The Nkx2-5 homeodomain protein plays a key role in cardiomyogenesis. Ectopic expression in frog and zebrafish embryos results in an enlarged myocardium; however, expression of Nkx2-5 in fibroblasts was not able to trigger the development of beating cardiac muscle. In order to examine the ability of Nkx2-5 to modulate endogenous cardiac specific gene expression in cells undergoing early stages of differentiation, P19 cell lines overexpressing Nkx2-5 were differentiated in the absence of Me2SO. Nkx2-5 expression induced cardiomyogenesis in these cultures aggregated without Me2SO. During differentiation into cardiac muscle, Nkx2-5 expression resulted in the activation of myocyte enhancer factor 2C (MEF2C), but not MEF2A, -B, or -D. In order to compare the abilities of Nkx2-5 and MEF2C to induce cellular differentiation, P19 cells overexpressing MEF2C were aggregated in the absence of Me2SO. Similar to Nkx2-5, MEF2C expression initiated cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. These findings indicate the presence of a positive regulatory network between Nkx2-5 and MEF2C and show that both factors can direct early stages of cell differentiation into a cardiomyogenic pathway."xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.52.34904"xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/author | "Skerjanc I.S."xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/author | "Petropoulos H."xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/author | "Ridgeway A.G."xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/author | "Wilton S."xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/pages | "34904-34910"xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/title | "Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells."xsd:string |
| http://purl.uniprot.org/citations/9857019 | http://purl.uniprot.org/core/volume | "273"xsd:string |
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