| http://purl.uniprot.org/citations/9869640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9869640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9869640 | http://www.w3.org/2000/01/rdf-schema#comment | "The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative regulation of hypoxia-inducible genes. Elongin B is a ubiquitin-like protein, and Elongin C is a Skp1-like protein that binds to a BC-box motif that is present in both Elongin A and VHL and is distinct from the conserved F-box motif recognized by Skp1. In this report, we demonstrate that the Elongin BC complex also binds to a functional BC box present in the SOCS box, a sequence motif identified recently in the suppressor of cytokine signaling-1 (SOCS-1) protein, as well as in a collection of additional proteins belonging to the SOCS, ras, WD-40 repeat, SPRY domain, and ankyrin repeat families. In addition, we present evidence (1) that the Elongin BC complex is a component of a multiprotein SOCS-1 complex that attenuates Jak/STAT signaling by binding to Jak2 and inhibiting Jak2 kinase, and (2) that by interacting with the SOCS box, the Elongin BC complex can increase expression of the SOCS-1 protein by inhibiting its degradation. These results suggest that Elongin BC is a multifunctional regulatory complex capable of controlling multiple pathways in the cell through interaction with a short degenerate sequence motif found in many different proteins."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.12.24.3872"xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.12.24.3872"xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Kamura T."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Kamura T."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Haque D."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/author | "Haque D."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/pages | "3872-3881"xsd:string |
| http://purl.uniprot.org/citations/9869640 | http://purl.uniprot.org/core/pages | "3872-3881"xsd:string |