| http://purl.uniprot.org/citations/9915703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9915703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9915703 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B (NF-kappaB) activation. Normally, these signals are generated only after TNF-induced receptor aggregation. However, TNF-R1 self-associates and signals independently of ligand when overexpressed. This apparent paradox may be explained by silencer of death domains (SODD), a widely expressed approximately 60-kilodalton protein that was found to be associated with the death domain of TNF-R1. TNF treatment released SODD from TNF-R1, permitting the recruitment of proteins such as TRADD and TRAF2 to the active TNF-R1 signaling complex. SODD also interacted with death receptor-3 (DR3), another member of the TNF receptor superfamily. Thus, SODD association may be representative of a general mechanism for preventing spontaneous signaling by death domain-containing receptors."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.283.5401.543"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.283.5401.543"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Goeddel D.V."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Goeddel D.V."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Woronicz J.D."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/author | "Woronicz J.D."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/pages | "543-546"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/pages | "543-546"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/title | "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/title | "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/9915703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9915703 |
| http://purl.uniprot.org/citations/9915703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9915703 |