| http://purl.uniprot.org/citations/9916915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9916915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9916915 | http://www.w3.org/2000/01/rdf-schema#comment | "Tcf-4 is a member of the Tcf/Lef family of transcription factors that interact functionally with beta-catenin to mediate Wnt signaling in vertebrates. We have previously demonstrated that the tumor suppressor function of APC in the small intestine is mediated via regulation of Tcf-4/beta-catenin transcriptional activity. To gain further insight into the role of Tcf-4 in development and carcinogenesis we have generated several mouse monoclonal antibodies, one of which is specific for Tcf-4 and another of which recognizes both Tcf-3 and Tcf-4. Immunohistochemistry performed with the Tcf 4-specific monoclonal antibody revealed high levels of expression in normal intestinal and mammary epithelium and carcinomas derived therefrom. Additional sites of Tcf-3 expression, as revealed by staining with the Tcf-3/-4 antibody, occurred only within the stomach epithelium, hair follicles, and keratinocytes of the skin. A temporal Tcf-4 expression gradient was observed along the crypt-villus axis of human small intestinal epithelium: strong Tcf-4 expression was present within the crypts of early (week 16) human fetal small intestine, with the villi showing barely detectable Tcf-4 protein levels. Tcf-4 expression levels increased dramatically on the villi of more highly developed (week 22) fetal small intestine. We conclude that Tcf-4 exhibits a highly restricted expression pattern related to the developmental stage of the intestinal epithelium. The high levels of Tcf-4 expression in mammary epithelium and mammary carcinomas may also indicate a role in the development of this tissue and breast carcinoma."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)65247-9"xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)65247-9"xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Barker N."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Barker N."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Korinek V."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Korinek V."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Huls G."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/author | "Huls G."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/pages | "29-35"xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/pages | "29-35"xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/title | "Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/title | "Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium."xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/9916915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9916915 |
| http://purl.uniprot.org/citations/9916915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9916915 |