| http://purl.uniprot.org/citations/9931453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9931453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9931453 | http://www.w3.org/2000/01/rdf-schema#comment | "The cloning and analysis of the first identified lysophosphatidic acid (LPA) receptor gene, lpA1 (also referred to as vzg-1 or edg-2), led us to identify homologous murine genes that might also encode receptors for related lysophospholipid ligands. Three murine genomic clones (designated lpB1, lpB2, and lpB3) were isolated, corresponding to human/rat Edg-1, rat H218/AGR16, and human edg-3, respectively. Based on the amino acid similarities of their predicted proteins (44-52% identical), the three lpB genes could be grouped into a separate G-protein coupled receptor subfamily, distinct from that containing the LPA receptor genes lpA1 and lpA2. Unlike lpA1 and lpA2, which contain multiple coding exons, all lpB members contained a single coding exon. Heterologous expression of individual lpB members in a hepatoma cell line (RH7777), followed by 35S-GTPgammaS incorporation assays demonstrated that each of the three LPB receptors conferred sphingosine-1-phosphate-dependent, but not lysophosphatidic acid-dependent, G-protein activation. Northern blot and in situ hybridization analyses revealed overlapping as well as distinct expression patterns in both embryonic and adult tissues. This comparative characterization of multiple sphingosine-1-phosphate receptor genes and their spatiotemporal expression patterns will aid in understanding the biological roles of this enlarging lysophospholipid receptor family."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(98)00589-7"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(98)00589-7"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Chun J."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Chun J."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Weiner J.A."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Weiner J.A."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Fukushima N."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Fukushima N."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Contos J.J.A."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/author | "Contos J.J.A."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/pages | "89-99"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/pages | "89-99"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/title | "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/title | "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/volume | "227"xsd:string |
| http://purl.uniprot.org/citations/9931453 | http://purl.uniprot.org/core/volume | "227"xsd:string |