| http://purl.uniprot.org/citations/9949182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9949182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9949182 | http://www.w3.org/2000/01/rdf-schema#comment | "In patients with an atypical stem-cell myeloproliferative disorder with lymphoma (B or T cell), myeloid hyperplasia, and eosinophilia, the chromosome 8p11-12 region is the site of a recurrent breakpoint that can be associated with three different partners, 6q27, 9q32-34, and 13q12. Rearrangements are supposed to affect a pluripotent stem cell capable of myeloid and lymphoid differentiation and to involve the same 8p11-12 gene. The t(8;13) translocation has recently been shown to result in a fusion between the FGFR1 gene that encodes a tyrosine kinase receptor for fibroblast growth factors and a novel gene, FIM (also called RAMP or ZNF198), belonging to a novel family of zinc finger genes. In the present study, we have cloned the t(6;8)(q27;p11) translocation in two patients and found a fusion between FGFR1 and a novel gene, FOP (FGFR1 Oncogene Partner), located on chromosome band 6q27. This gene is alternatively spliced and ubiquitously expressed. It encodes a protein containing two regions of putative leucine-rich repeats putatively folding in alpha-helices and separated by a hydrophobic spacer. The two reciprocal fusion transcripts were evidenced by reverse transcription-polymerase chain reaction in the tumoral cells of the patients. The predicted chimeric FOP-FGFR1 protein contains the FOP N-terminus leucine-rich region fused to the catalytic domain of FGFR1. It may promote hematopoietic stem cell proliferation and leukemogenesis through a constitutive phosphorylation and activation of the downstream pathway of FGFR1."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Jonveaux P."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Jonveaux P."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Birnbaum D."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Birnbaum D."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Gregoire M.-J."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Gregoire M.-J."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Lafage-Pochitaloff M."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Lafage-Pochitaloff M."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Pebusque M.-J."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Pebusque M.-J."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Popovici C."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/author | "Popovici C."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/pages | "1381-1389"xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/pages | "1381-1389"xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/title | "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1."xsd:string |
| http://purl.uniprot.org/citations/9949182 | http://purl.uniprot.org/core/title | "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1."xsd:string |