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Literature citations Results

Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans.

Burnett A.L., Calvin D.C., Chamness S.L., Liu J.X., Nelson R.J., Klein S.L., Dawson V.L., Dawson T.M., Snyder S.H.

Nat. Med. 3:571-574(1997) · Mapped (4)

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

Andres-Mateos E., Mejias R., Sasaki M., Li X., Lin B.M., Biskup S., Zhang L., Banerjee R., Thomas B., Yang L. et al.

J. Neurosci. 29:15846-15850(2009) · Mapped (3)

TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF.

Nam J.H., Park E.S., Won S.Y., Lee Y.A., Kim K.I., Jeong J.Y., Baek J.Y., Cho E.J., Jin M., Chung Y.C. et al.

Brain 138:3610-3622(2015) · Mapped (6)

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.

Nikonova E.V., Xiong Y., Tanis K.Q., Dawson V.L., Vogel R.L., Finney E.M., Stone D.J., Reynolds I.J., Kern J.T., Dawson T.M.

Hum. Mol. Genet. 21:163-174(2012) · Mapped (8)

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.

Umanah G.K.E., Pignatelli M., Yin X., Chen R., Crawford J., Neifert S., Scarffe L., Behensky A.A., Guiberson N., Chang M. et al.

Sci Transl Med 9:0-0(2017) · Mapped (5)

The road to survival goes through PARG.

Koh D.W., Dawson V.L., Dawson T.M.

Cell Cycle 4:397-399(2005) · Mapped (5)

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.

Ando M., Fiesel F.C., Hudec R., Caulfield T.R., Ogaki K., Gorka-Skoczylas P., Koziorowski D., Friedman A., Chen L., Dawson V.L. et al.

Mol Neurodegener 12:32-32(2017) · Mapped (1)

The orphan nuclear receptor, steroidogenic factor 1, regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes.

Wei X., Sasaki M., Huang H., Dawson V.L., Dawson T.M.

Mol. Endocrinol. 16:2828-2839(2002) · Mapped (6)

The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice.

Pol O., Sasaki M., Jimenez N., Dawson V.L., Dawson T.M., Puig M.M.

Br. J. Pharmacol. 145:758-766(2005) · Mapped (3)

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

Wang L., Xie C., Greggio E., Parisiadou L., Shim H., Sun L., Chandran J., Lin X., Lai C., Yang W.J. et al.

J. Neurosci. 28:3384-3391(2008) · Mapped (21)

The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.

Zhang J., Wang Y., Chi Z., Keuss M.J., Pai Y.M., Kang H.C., Shin J.H., Bugayenko A., Wang H., Xiong Y. et al.

Cell 145:284-299(2011) · UniProtKB (6) · Mapped (33)

T cells from patients with Parkinson's disease recognize alpha-synuclein peptides.

Sulzer D., Alcalay R.N., Garretti F., Cote L., Kanter E., Agin-Liebes J., Liong C., McMurtrey C., Hildebrand W.H., Mao X. et al.

Nature 546:656-661(2017) · Mapped (8)

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

Engelender S., Kaminsky Z., Guo X., Sharp A.H., Amaravi R.K., Kleiderlein J.J., Margolis R.L., Troncoso J.C., Lanahan A., Worley P.F. et al.

Nat. Genet. 22:110-114(1999) · UniProtKB (1) · Mapped (4)

Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning.

Pignatelli M., Umanah G.K.E., Ribeiro S.P., Chen R., Karuppagounder S.S., Yau H.J., Eacker S., Dawson V.L., Dawson T.M., Bonci A.

Neuron 93:425-440(2017) · Mapped (10)

Sulfhydration mediates neuroprotective actions of parkin.

Vandiver M.S., Paul B.D., Xu R., Karuppagounder S., Rao F., Snowman A.M., Ko H.S., Lee Y.I., Dawson V.L., Dawson T.M. et al.

Nat Commun 4:1626-1626(2013) · Mapped (23)

Stroke outcome in double-mutant antioxidant transgenic mice.

Sampei K., Mandir A.S., Asano Y., Wong P.C., Traystman R.J., Dawson V.L., Dawson T.M., Hurn P.D.

Stroke 31:2685-2691(2000) · Mapped (4)

Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain.

Poitras M.F., Koh D.W., Yu S.W., Andrabi S.A., Mandir A.S., Poirier G.G., Dawson V.L., Dawson T.M.

Neuroscience 148:198-211(2007) · Mapped (22)

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.

Tsang A.H., Lee Y.I., Ko H.S., Savitt J.M., Pletnikova O., Troncoso J.C., Dawson V.L., Dawson T.M., Chung K.K.

Proc. Natl. Acad. Sci. U.S.A. 106:4900-4905(2009) · Mapped (3)

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

Chung K.K.K., Thomas B., Li X., Pletnikova O., Troncoso J.C., Marsh L., Dawson V.L., Dawson T.M.

Science 304:1328-1331(2004) · UniProtKB (2) · Mapped (32)

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.

Xiong Y., Neifert S., Karuppagounder S.S., Liu Q., Stankowski J.N., Lee B.D., Ko H.S., Lee Y., Grima J.C., Mao X. et al.

Proc. Natl. Acad. Sci. U.S.A. 115:1635-1640(2018) · Mapped (3)

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.

Martin I., Kim J.W., Lee B.D., Kang H.C., Xu J.C., Jia H., Stankowski J., Kim M.S., Zhong J., Kumar M. et al.

Cell 157:472-485(2014) · Mapped (181)

Resistance to MPTP-neurotoxicity in alpha-synuclein knockout mice is complemented by human alpha-synuclein and associated with increased beta-synuclein and Akt activation.

Thomas B., Mandir A.S., West N., Liu Y., Andrabi S.A., Stirling W., Dawson V.L., Dawson T.M., Lee M.K.

PLoS ONE 6:e16706-e16706(2011) · Mapped (17)

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.

Wong E.S., Tan J.M., Wang C., Zhang Z., Tay S.P., Zaiden N., Ko H.S., Dawson V.L., Dawson T.M., Lim K.L.

J. Biol. Chem. 282:12310-12318(2007) · Mapped (23)

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2.

Li X., Moore D.J., Xiong Y., Dawson T.M., Dawson V.L.

J. Biol. Chem. 285:29569-29576(2010) · Mapped (8)

Protein microarray characterization of the S-nitrosoproteome.

Lee Y.I., Giovinazzo D., Kang H.C., Lee Y., Jeong J.S., Doulias P.T., Xie Z., Hu J., Ghasemi M., Ischiropoulos H. et al.

Mol. Cell Proteomics 13:63-72(2014)

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