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Literature citations Results

Citation
Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Atlasi Y., Noori R., Gaspar C., Franken P., Sacchetti A., Rafati H., Mahmoudi T., Decraene C., Calin G.A., Merrill B.J. et al.

PLoS Genet. 9:e1003424-e1003424(2013) · Mapped (25)

The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.

Atlasi Y., Noori R., Marolin I., Franken P., Brandao J., Biermann K., Collini P., Grigorian M., Lukanidin E., Ambartsumian N. et al.

Eur. J. Cancer 68:114-124(2016) · Mapped (4)

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

Albuquerque C., Breukel C., van der Luijt R., Fidalgo P., Lage P., Slors F.J., Leitao C.N., Fodde R., Smits R.

Hum. Mol. Genet. 11:1549-1560(2002) · Mapped (49)

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.

van der Houven van Oordt C.W., Smits R., Schouten T.G., Houwing-Duistermaat J.J., Williamson S.L., Luz A., Meera Khan P., van der Eb A.J., Breuer M.L., Fodde R.

Genes Chromosomes Cancer 24:191-198(1999) · Mapped (15)

The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function.

Yokoyama A., Nomura R., Kurosumi M., Shimomura A., Onouchi T., Iizuka-Kogo A., Smits R., Oda N., Fodde R., Itoh M. et al.

Med Mol Morphol 44:207-212(2011) · Mapped (8)

TGFBR1*6A may contribute to hereditary colorectal cancer.

Bian Y., Caldes T., Wijnen J., Franken P., Vasen H., Kaklamani V., Nafa K., Peterlongo P., Ellis N., Baron J.A. et al.

J. Clin. Oncol. 23:3074-3078(2005) · Mapped (6)

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.

Onouchi T., Kobayashi K., Sakai K., Shimomura A., Smits R., Sumi-Ichinose C., Kurosumi M., Takao K., Nomura R., Iizuka-Kogo A. et al.

Mol Brain 7:21-21(2014) · Mapped (8)

Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.

Yokoyama A., Nomura R., Kurosumi M., Shimomura A., Onouchi T., Iizuka-Kogo A., Smits R., Fodde R., Itoh M., Senda T.

Med Mol Morphol 45:161-167(2012) · Mapped (8)

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.

Smits R., Hofland N., Edelmann W., Geugien M., Jagmohan-Changur S., Albuquerque C., Breukel C., Kucherlapati R., Kielman M.F., Fodde R.

Genes Chromosomes Cancer 29:229-239(2000) · Mapped (27)

Smad4 haploinsufficiency in mouse models for intestinal cancer.

Alberici P., Jagmohan-Changur S., De Pater E., Van Der Valk M., Smits R., Hohenstein P., Fodde R.

Oncogene 25:1841-1851(2006) · Mapped (17)

Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice.

Sorensen I.K., Kristiansen E., Mortensen A., van Kranen H., van Kreijl C., Fodde R., Thorgeirsson S.S.

Carcinogenesis 18:777-781(1997) · Mapped (12)

Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors.

Lorenz A., Deutschmann M., Ahlfeld J., Prix C., Koch A., Smits R., Fodde R., Kretzschmar H.A., Schuller U.

Mol. Cell. Biol. 31:3326-3338(2011) · Mapped (75)

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.

Wijnen J., Vasen H., Khan P.M., Menko F.H., van der Klift H., van Leeuwen C., van den Broek M., van Leeuwen-Cornelisse I., Nagengast F., Meijers-Heijboer A. et al.

Am. J. Hum. Genet. 56:1060-1066(1995) · UniProtKB (8)

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.

Hohenstein P., Molenaar L., Elsinga J., Morreau H., van der Klift H., Struijk A., Jagmohan-Changur S., Smits R., van Kranen H., van Ommen G.J. et al.

Genes Chromosomes Cancer 36:273-282(2003) · UniProtKB (1) · Mapped (13)

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

Schewe M., Franken P.F., Sacchetti A., Schmitt M., Joosten R., Bottcher R., van Royen M.E., Jeammet L., Payre C., Scott P.M. et al.

Cell Stem Cell 19:38-51(2016) · Mapped (7)

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.

Drabek K., van Ham M., Stepanova T., Draegestein K., van Horssen R., Sayas C.L., Akhmanova A., Ten Hagen T., Smits R., Fodde R. et al.

Curr. Biol. 16:2259-2264(2006) · Mapped (34)

Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer.

Fijneman R.J., de Wit M., Pourghiasian M., Piersma S.R., Pham T.V., Warmoes M.O., Lavaei M., Piso C., Smit F., Delis-van Diemen P.M. et al.

Clin. Cancer Res. 18:2613-2624(2012) · Mapped (5)

Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta.

Siezen C.L., Tijhuis M.J., Kram N.R., van Soest E.M., de Jong D.J., Fodde R., van Kranen H.J., Kampman E.

Pharmacogenet. Genomics 16:43-50(2006) · Mapped (26)

Of mice and (wo)men: genotype-phenotype correlations in BRCA1.

Hohenstein P., Fodde R.

Hum. Mol. Genet. 12 Spec No 2:R271-7(2003) · Mapped (9)

Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis.

van der Luijt R.B., Meera Khan P., Vasen H.F.A., Tops C.M.J., van Leeuwen-Cornelisse I.S.J., Wijnen J.T., van der Klift H.M., Plug R.J., Griffioen G., Fodde R.

Hum. Mutat. 9:7-16(1997) · UniProtKB (1)

Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene.

Wagner A., Barrows A., Wijnen J.T., van der Klift H., Franken P.F., Verkuijlen P., Nakagawa H., Geugien M., Jaghmohan-Changur S., Breukel C. et al.

Am. J. Hum. Genet. 72:1088-1100(2003) · UniProtKB (3) · Mapped (22)

Mechanisms of APC-driven tumorigenesis: lessons from mouse models.

Fodde R., Smits R., Hofland N., Kielman M., Meera Khan P.

Cytogenet. Cell Genet. 86:105-111(1999) · Mapped (12)

Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.

Kong Y., Poon R., Nadesan P., Di Muccio T., Fodde R., Khokha R., Alman B.A.

Cancer Res. 64:5795-5803(2004) · Mapped (12)

Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16.

Wijnen J., Khan P.M., Vasen H., Menko F., van der Klift H., van den Broek M., van Leeuwen-Cornelisse I., Nagengast F., Meijers-Heijboer E.J., Lindhout D. et al.

Am. J. Hum. Genet. 58:300-307(1996) · UniProtKB (1)

Loss of APC function in mesenchymal cells surrounding the Mullerian duct leads to myometrial defects in adult mice.

Wang Y., Jia Y., Franken P., Smits R., Ewing P.C., Lydon J.P., DeMayo F.J., Burger C.W., Anton Grootegoed J., Fodde R. et al.

Mol. Cell. Endocrinol. 341:48-54(2011) · Mapped (18)

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