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Literature citations Results

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease.

Tufarelli C., Stanley J.A., Garrick D., Sharpe J.A., Ayyub H., Wood W.G., Higgs D.R.

Nat. Genet. 34:157-165(2003) · Mapped (11)

The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.

Berube N.G., Mangelsdorf M., Jagla M., Vanderluit J., Garrick D., Gibbons R.J., Higgs D.R., Slack R.S., Picketts D.J.

J. Clin. Invest. 115:258-267(2005) · Mapped (25)

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.

Gibbons R.J., McDowell T.L., Raman S., O'Rourke D.M., Garrick D., Ayyub H., Higgs D.R.

Nat. Genet. 24:368-371(2000)

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.

Garrick D., Sharpe J.A., Arkell R., Dobbie L., Smith A.J., Wood W.G., Higgs D.R., Gibbons R.J.

PLoS Genet. 2:e58-e58(2006) · Mapped (32)

Intragenic enhancers act as alternative promoters.

Kowalczyk M.S., Hughes J.R., Garrick D., Lynch M.D., Sharpe J.A., Sloane-Stanley J.A., McGowan S.J., De Gobbi M., Hosseini M., Vernimmen D. et al.

Mol. Cell 45:447-458(2012) · Mapped (16)

Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).

Gibbons R.J., Pellagatti A., Garrick D., Wood W.G., Malik N., Ayyub H., Langford C., Boultwood J., Wainscoat J.S., Higgs D.R.

Nat. Genet. 34:446-449(2003) · UniProtKB (1)

Distinct factors control histone variant H3.3 localization at specific genomic regions.

Goldberg A.D., Banaszynski L.A., Noh K.M., Lewis P.W., Elsaesser S.J., Stadler S., Dewell S., Law M., Guo X., Li X. et al.

Cell 140:678-691(2010) · UniProtKB (2) · Mapped (78)

Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.

Muers M.R., Sharpe J.A., Garrick D., Sloane-Stanley J., Nolan P.M., Hacker T., Wood W.G., Higgs D.R., Gibbons R.J.

Am. J. Hum. Genet. 80:1138-1149(2007) · Mapped (23)

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.

van de Lagemaat L.N., Flenley M., Lynch M.D., Garrick D., Tomlinson S.R., Kranc K.R., Vernimmen D.

Epigenetics Chromatin 11:59-59(2018) · Mapped (4)

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.

Eustermann S., Yang J.C., Law M.J., Amos R., Chapman L.M., Jelinska C., Garrick D., Clynes D., Gibbons R.J., Rhodes D. et al.

Nat. Struct. Mol. Biol. 18:777-782(2011) · UniProtKB (2) · Mapped (1)

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

Law M.J., Lower K.M., Voon H.P., Hughes J.R., Garrick D., Viprakasit V., Mitson M., De Gobbi M., Marra M., Morris A. et al.

Cell 143:367-378(2010) · UniProtKB (2) · Mapped (9)

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.

Lynch M.D., Smith A.J., De Gobbi M., Flenley M., Hughes J.R., Vernimmen D., Ayyub H., Sharpe J.A., Sloane-Stanley J.A., Sutherland L. et al.

EMBO J. 31:317-329(2012) · Mapped (41)

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation.

Djeghloul D., Kuranda K., Kuzniak I., Barbieri D., Naguibneva I., Choisy C., Bories J.C., Dosquet C., Pla M., Vanneaux V. et al.

Stem Cell Reports 6:970-984(2016) · Mapped (6)

A novel nonsense mutation in the DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep.

Zhao X., Dittmer K.E., Blair H.T., Thompson K.G., Rothschild M.F., Garrick D.J.

PLoS ONE 6:e21739-e21739(2011) · UniProtKB (1)

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