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Literature citations Results

Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas.

Lin H.J., Probst-Hensch N.M., Hughes N.C., Sakamoto G.T., Louie A.D., Kau I.H., Lin B.K., Lee D.B., Lin J., Frankl H.D. et al.

Pharmacogenetics 8:269-281(1998) · UniProtKB (1)

TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA.

Perrot I., Deauvieau F., Massacrier C., Hughes N., Garrone P., Durand I., Demaria O., Viaud N., Gauthier L., Blery M. et al.

J. Immunol. 185:2080-2088(2010) · Mapped (10)

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

Webster J.D., Pham T.H., Wu X., Hughes N.W., Li Z., Totpal K., Lee H.J., Calses P.C., Chaurushiya M.S., Stawiski E.W. et al.

Pigment Cell Melanoma Res 32:269-279(2019) · Mapped (6)

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17.

Kennedy C.L., Najdovska M., Jones G.W., McLeod L., Hughes N.R., Allison C., Ooi C.H., Tan P., Ferrero R.L., Jones S.A. et al.

J. Pathol. 225:255-264(2011) · Mapped (31)

The alpha-fetoprotein promoter is the target of Afr1-mediated postnatal repression.

Peyton D.K., Huang M.C., Giglia M.A., Hughes N.K., Spear B.T.

Genomics 63:173-180(2000) · Mapped (2)

Structure-based design and optimization of potent inhibitors of the adenoviral protease.

Grosche P., Sirockin F., Mac Sweeney A., Ramage P., Erbel P., Melkko S., Bernardi A., Hughes N., Ellis D., Combrink K.D. et al.

Bioorg. Med. Chem. Lett. 25:438-443(2015) · UniProtKB (2)

Structural determinants of MALT1 protease activity.

Wiesmann C., Leder L., Blank J., Bernardi A., Melkko S., Decock A., D'Arcy A., Villard F., Erbel P., Hughes N. et al.

J. Mol. Biol. 419:4-21(2012) · Mapped (7)

STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.

Tye H., Kennedy C.L., Najdovska M., McLeod L., McCormack W., Hughes N., Dev A., Sievert W., Ooi C.H., Ishikawa T.O. et al.

Cancer Cell 22:466-478(2012) · Mapped (49)

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

Ernst M., Najdovska M., Grail D., Lundgren-May T., Buchert M., Tye H., Matthews V.B., Armes J., Bhathal P.S., Hughes N.R. et al.

J. Clin. Invest. 118:1727-1738(2008) · Mapped (46)

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Maibaum J., Liao S.M., Vulpetti A., Ostermann N., Randl S., Rudisser S., Lorthiois E., Erbel P., Kinzel B., Kolb F.A. et al.

Nat. Chem. Biol. 12:1105-1110(2016) · Mapped (3)

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Schubart A., Anderson K., Mainolfi N., Sellner H., Ehara T., Adams C.M., Mac Sweeney A., Liao S.M., Crowley M., Littlewood-Evans A. et al.

Proc. Natl. Acad. Sci. U.S.A. 116:7926-7931(2019) · Mapped (1)

Rapid mapping and identification of mutations in Caenorhabditis elegans by restriction site-associated DNA mapping and genomic interval pull-down sequencing.

O'Rourke S.M., Yochem J., Connolly A.A., Price M.H., Carter L., Lowry J.B., Turnbull D.W., Kamps-Hughes N., Stiffler N., Miller M.R. et al.

Genetics 189:767-778(2011) · Mapped (4)

Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A.

Stanescu D.E., Hughes N., Kaplan B., Stanley C.A., De Leon D.D.

J. Clin. Endocrinol. Metab. 97:E2026-2030(2012) · UniProtKB (1) · Mapped (27)

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

Jones S.B., Pfeifer L.A., Bleisch T.J., Beauchamp T.J., Durbin J.D., Klimkowski V.J., Hughes N.E., Rito C.J., Dao Y., Gruber J.M. et al.

ACS Med. Chem. Lett. 7:857-861(2016) · UniProtKB (1)

Mannanase A from Pseudomonas fluorescens ssp. cellulosa is a retaining glycosyl hydrolase in which E212 and E320 are the putative catalytic residues.

Bolam D.N., Hughes N., Virden R., Lakey J.H., Hazlewood G.P., Henrissat B., Braithwaite K.L., Gilbert H.J.

Biochemistry 35:16195-16204(1996) · UniProtKB (1)

Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter.

Velayudhan J., Hughes N.J., McColm A.A., Bagshaw J., Clayton C.L., Andrews S.C., Kelly D.J.

Mol. Microbiol. 37:274-286(2000) · UniProtKB (1)

Identification of potent and selective retinoic acid receptor gamma (RARgamma) antagonists for the treatment of osteoarthritis pain using structure based drug design.

Hughes N.E., Bleisch T.J., Jones S.A., Richardson T.I., Doti R.A., Wang Y., Stout S.L., Durst G.L., Chambers M.G., Oskins J.L. et al.

Bioorg. Med. Chem. Lett. 26:3274-3277(2016) · Mapped (1)

Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia.

Zhou J., Kherani F., Bardakjian T.M., Katowitz J., Hughes N., Schimmenti L.A., Schneider A., Young T.L.

Mol. Vis. 14:583-592(2008) · Mapped (23)

Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate:flavodoxin oxidoreductase from Helicobacter pylori.

Hughes N.J., Chalk P.A., Clayton C.L., Kelly D.J.

J. Bacteriol. 177:3953-3959(1995) · UniProtKB (14)

Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe.

Hughes N.C., Janezic S.A., McQueen K.L., Jewett M.A., Castranio T., Bell D.A., Grant D.M.

Pharmacogenetics 8:55-66(1998) · UniProtKB (1)

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors.

Ahmadi M., Ahmadihosseini Z., Allison S.J., Begum S., Rockley K., Sadiq M., Chintamaneni S., Lokwani R., Hughes N., Phillips R.M.

Br. J. Pharmacol. 171:224-236(2014) · Mapped (1)

Hepatocyte nuclear factor 4alpha gene mutation associated with familial neonatal hyperinsulinism and maturity-onset diabetes of the young.

Pingul M.M., Hughes N., Wu A., Stanley C.A., Gruppuso P.A.

J. Pediatr. 158:852-854(2011) · Mapped (20)

Helicobacter pylori porCDAB and oorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases which mediate electron transport to NADP.

Hughes N.J., Clayton C.L., Chalk P.A., Kelly D.J.

J. Bacteriol. 180:1119-1128(1998) · UniProtKB (10) · Mapped (4)

Genome-wide identification of hypoxia-induced enhancer regions.

Kamps-Hughes N., Preston J.L., Randel M.A., Johnson E.A.

PeerJ 3:e1527-e1527(2015) · Mapped (43)

Familial recurrence of SOX2 anophthalmia syndrome: phenotypically normal mother with two affected daughters.

Schneider A., Bardakjian T.M., Zhou J., Hughes N., Keep R., Dorsainville D., Kherani F., Katowitz J., Schimmenti L.A., Hummel M. et al.

Am. J. Med. Genet. A 146A:2794-2798(2008) · Mapped (8)

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