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Literature citations Results

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

Hao H.X., Xie Y., Zhang Y., Charlat O., Oster E., Avello M., Lei H., Mickanin C., Liu D., Ruffner H. et al.

Nature 485:195-200(2012) · UniProtKB (11) · Mapped (23)

What controls the cell cycle?

Murray A.W., Kirschner M.W.

Sci. Am. 264:56-63(1991) · Mapped (3)

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.

Yan C., Martinez-Quiles N., Eden S., Shibata T., Takeshima F., Shinkura R., Fujiwara Y., Bronson R., Snapper S.B., Kirschner M.W. et al.

EMBO J. 22:3602-3612(2003) · Mapped (15)

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.

Zhang J., Wu T., Simon J., Takada M., Saito R., Fan C., Liu X.D., Jonasch E., Xie L., Chen X. et al.

Science 361:290-295(2018) · Mapped (1)

UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

Wu T., Merbl Y., Huo Y., Gallop J.L., Tzur A., Kirschner M.W.

Proc. Natl. Acad. Sci. U.S.A. 107:1355-1360(2010) · Mapped (3)

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

Ayad N.G., Rankin S., Murakami M., Jebanathirajah J., Gygi S.P., Kirschner M.W.

Cell 113:101-113(2003) · UniProtKB (3)

Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.

Ho H.-Y.H., Rohatgi R., Lebensohn A.M., Ma L., Li J., Gygi S.P., Kirschner M.W.

Cell 118:203-216(2004) · UniProtKB (3) · Mapped (27)

Timing of events in mitosis.

Georgi A.B., Stukenberg P.T., Kirschner M.W.

Curr. Biol. 12:105-114(2002) · UniProtKB (9)

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex.

Song M.S., Song S.J., Ayad N.G., Chang J.S., Lee J.H., Hong H.K., Lee H., Choi N., Kim J., Kim H. et al.

Nat. Cell Biol. 6:129-137(2004) · UniProtKB (1) · Mapped (4)

The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.

Philpott A., Porro E.B., Kirschner M.W., Tsai L.H.

Genes Dev. 11:1409-1421(1997) · UniProtKB (1)

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.

Song E.J., Werner S.L., Neubauer J., Stegmeier F., Aspden J., Rio D., Harper J.W., Elledge S.J., Kirschner M.W., Rape M.

Genes Dev. 24:1434-1447(2010) · UniProtKB (5)

The processivity of multiubiquitination by the APC determines the order of substrate degradation.

Rape M., Reddy S.K., Kirschner M.W.

Cell 124:89-103(2006) · Mapped (71)

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.

Wang W., Wu T., Kirschner M.W.

Elife 3:e03083-e03083(2014) · Mapped (3)

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.

Pfleger C.M., Kirschner M.W.

Genes Dev. 14:655-665(2000) · Mapped (22)

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

Rohatgi R., Ma L., Miki H., Lopez M., Kirchhausen T., Takenawa T., Kirschner M.W.

Cell 97:221-231(1999) · Mapped (42)

The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development.

Kinoshita N., Minshull J., Kirschner M.W.

Cell 83:621-630(1995) · UniProtKB (2)

The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.

Hanschen E.R., Marriage T.N., Ferris P.J., Hamaji T., Toyoda A., Fujiyama A., Neme R., Noguchi H., Minakuchi Y., Suzuki M. et al.

Nat Commun 7:11370-11370(2016) · UniProtKB (16,224)

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.

Shen M., Stukenberg P.T., Kirschner M.W., Lu K.P.

Genes Dev. 12:706-720(1998) · UniProtKB (1)

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.

Rickmyre J.L., Dasgupta S., Ooi D.L., Keel J., Lee E., Kirschner M.W., Waddell S., Lee L.A.

J. Cell. Sci. 120:3565-3577(2007) · UniProtKB (1) · Mapped (33)

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

Fang G., Yu H., Kirschner M.W.

Genes Dev. 12:1871-1883(1998) · UniProtKB (2)

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

Wan L., Chen M., Cao J., Dai X., Yin Q., Zhang J., Song S.J., Lu Y., Liu J., Inuzuka H. et al.

Cancer Discov 7:424-441(2017) · Mapped (56)

Tau protein binds to microtubules through a flexible array of distributed weak sites.

Butner K.A., Kirschner M.W.

J. Cell Biol. 115:717-730(1991)

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

Himmler A., Drechsel D., Kirschner M.W., Martin D.W. Jr.

Mol. Cell. Biol. 9:1381-1388(1989) · UniProtKB (3)

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang S.M., Mishina Y.M., Liu S., Cheung A., Stegmeier F., Michaud G.A., Charlat O., Wiellette E., Zhang Y., Wiessner S. et al.

Nature 461:614-620(2009) · UniProtKB (4) · Mapped (73)

Systematic identification of mitotic phosphoproteins.

Stukenberg P.T., Lustig K.D., McGarry T.J., King R.W., Kuang J., Kirschner M.W.

Curr. Biol. 7:338-348(1997) · UniProtKB (4)

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